tetano
Editor, Senior Moderator
PLoS One. 2013 Dec 11;8(12):e80034. doi: 10.1371/journal.pone.0080034.
Mechanisms of hemagglutinin targeted influenza virus neutralization.
Brandenburg B1, Koudstaal W1, Goudsmit J1, Klaren V1, Tang C1, Bujny MV1, Korse HJ1, Kwaks T1, Otterstrom JJ2, Juraszek J1, van Oijen AM3, Vogels R1, Friesen RH1.
Author information
Abstract
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.
PMID:
24348996
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24348996
Mechanisms of hemagglutinin targeted influenza virus neutralization.
Brandenburg B1, Koudstaal W1, Goudsmit J1, Klaren V1, Tang C1, Bujny MV1, Korse HJ1, Kwaks T1, Otterstrom JJ2, Juraszek J1, van Oijen AM3, Vogels R1, Friesen RH1.
Author information
Abstract
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.
PMID:
24348996
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24348996