tetano
Editor, Senior Moderator
mBio
. 2024 Nov 12:e0336823.
doi: 10.1128/mbio.03368-23. Online ahead of print. Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles
Grace Neilsen[SUP] #[/SUP][SUP] 1 2 [/SUP], Asha Maria Mathew[SUP] #[/SUP][SUP] 1 2 [/SUP], Jose M Castro[SUP] #[/SUP][SUP] 1 2 [/SUP], William M McFadden[SUP] 1 2 [/SUP], Xin Wen[SUP] 1 2 [/SUP], Yee T Ong[SUP] 1 2 [/SUP], Philip R Tedbury[SUP] 1 2 [/SUP], Shuiyun Lan[SUP] 1 2 [/SUP], Stefan G Sarafianos[SUP] 1 2 [/SUP]
Affiliations
The coronavirus-induced disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, has had a devastating impact on millions of lives globally, with severe mortality rates and catastrophic social implications. Developing tools for effective vaccine strategies and platforms is essential for controlling and preventing the recurrence of such pandemics. Moreover, molecular virology tools that facilitate the study of viral pathogens, impact of viral mutations, and interactions with various host proteins are essential. Viral replicon- and virus-like particle (VLP)-based systems are excellent examples of such tools. This review outlines the importance, advantages, and disadvantages of both the replicon- and VLP-based systems that have been developed for SARS-CoV-2 and have helped the scientific community in dimming the intensity of the COVID-19 pandemic.
Keywords: COVID-19; SARS-CoV-2; coronavirus; drug discovery; replicon; vaccines; virus-like particles.
. 2024 Nov 12:e0336823.
doi: 10.1128/mbio.03368-23. Online ahead of print. Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles
Grace Neilsen[SUP] #[/SUP][SUP] 1 2 [/SUP], Asha Maria Mathew[SUP] #[/SUP][SUP] 1 2 [/SUP], Jose M Castro[SUP] #[/SUP][SUP] 1 2 [/SUP], William M McFadden[SUP] 1 2 [/SUP], Xin Wen[SUP] 1 2 [/SUP], Yee T Ong[SUP] 1 2 [/SUP], Philip R Tedbury[SUP] 1 2 [/SUP], Shuiyun Lan[SUP] 1 2 [/SUP], Stefan G Sarafianos[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39530689
- DOI: 10.1128/mbio.03368-23
The coronavirus-induced disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, has had a devastating impact on millions of lives globally, with severe mortality rates and catastrophic social implications. Developing tools for effective vaccine strategies and platforms is essential for controlling and preventing the recurrence of such pandemics. Moreover, molecular virology tools that facilitate the study of viral pathogens, impact of viral mutations, and interactions with various host proteins are essential. Viral replicon- and virus-like particle (VLP)-based systems are excellent examples of such tools. This review outlines the importance, advantages, and disadvantages of both the replicon- and VLP-based systems that have been developed for SARS-CoV-2 and have helped the scientific community in dimming the intensity of the COVID-19 pandemic.
Keywords: COVID-19; SARS-CoV-2; coronavirus; drug discovery; replicon; vaccines; virus-like particles.