tetano
Editor, Senior Moderator
Mayo Clin Proc
. 2020 Aug;95(8):1613-1620.
doi: 10.1016/j.mayocp.2020.05.014. Epub 2020 May 29.
Sex Differences in Case Fatality Rate of COVID-19: Insights From a Multinational Registry
Mohamad Alkhouli[SUP] 1 [/SUP], Aravinda Nanjundappa[SUP] 2 [/SUP], Frank Annie[SUP] 3 [/SUP], Mark C Bates[SUP] 4 [/SUP], Deepak L Bhatt[SUP] 5 [/SUP]
Affiliations
Abstract
Objectives: To confirm whether a relationship exists between male sex and coronavirus disease 2019 (COVID-19) mortality and whether this relationship is age dependent.
Patients and methods: We queried the COVID-19 Research Network, a multinational database using the TriNetX network, to identify patients with confirmed COVID-19 infection. The main end point of the study was all-cause mortality.
Results: A total of 14,712 patients were included, of whom 6387 (43%) were men. Men were older (mean age, 55.0?17.7 years vs 51.1?17.9 years; P<.001) and had a higher prevalence of hypertension, diabetes, coronary disease, obstructive pulmonary disease, nicotine dependence, and heart failure but a lower prevalence of obesity. Before propensity score matching (PSM), all-cause mortality rate was 8.8% in men and 4.3% in women (odds ratio, 2.15; 95% CI, 1.87 to 2.46; P<.001) at a median follow-up duration of 34 and 32 days, respectively. In the Kaplan-Meier survival analysis, the cumulative probability of survival was significantly lower in men than in women (73% vs 86%; log-rank, P<.001). After PSM, all-cause mortality remained significantly higher in men than in women (8.13% vs 4.60%; odds ratio, 1.81; 95% CI, 1.55 to 2.11; P<.001). In the Kaplan-Meier survival analysis, the cumulative probability of survival remained significantly lower in men than in women (74% vs 86%; log-rank, P<.001). The cumulative probability of survival remained significantly lower in propensity score-matched men than in women after excluding patients younger than 50 years and those who were taking angiotensin-converting enzyme inhibitor or angiotensin receptor blocker medications on admission.
Conclusion: Among patients with COVID-19 infection, men had a significantly higher mortality than did women, and this difference was not completely explained by the higher prevalence of comorbidities in men.
. 2020 Aug;95(8):1613-1620.
doi: 10.1016/j.mayocp.2020.05.014. Epub 2020 May 29.
Sex Differences in Case Fatality Rate of COVID-19: Insights From a Multinational Registry
Mohamad Alkhouli[SUP] 1 [/SUP], Aravinda Nanjundappa[SUP] 2 [/SUP], Frank Annie[SUP] 3 [/SUP], Mark C Bates[SUP] 4 [/SUP], Deepak L Bhatt[SUP] 5 [/SUP]
Affiliations
- PMID: 32753136
- DOI: 10.1016/j.mayocp.2020.05.014
Abstract
Objectives: To confirm whether a relationship exists between male sex and coronavirus disease 2019 (COVID-19) mortality and whether this relationship is age dependent.
Patients and methods: We queried the COVID-19 Research Network, a multinational database using the TriNetX network, to identify patients with confirmed COVID-19 infection. The main end point of the study was all-cause mortality.
Results: A total of 14,712 patients were included, of whom 6387 (43%) were men. Men were older (mean age, 55.0?17.7 years vs 51.1?17.9 years; P<.001) and had a higher prevalence of hypertension, diabetes, coronary disease, obstructive pulmonary disease, nicotine dependence, and heart failure but a lower prevalence of obesity. Before propensity score matching (PSM), all-cause mortality rate was 8.8% in men and 4.3% in women (odds ratio, 2.15; 95% CI, 1.87 to 2.46; P<.001) at a median follow-up duration of 34 and 32 days, respectively. In the Kaplan-Meier survival analysis, the cumulative probability of survival was significantly lower in men than in women (73% vs 86%; log-rank, P<.001). After PSM, all-cause mortality remained significantly higher in men than in women (8.13% vs 4.60%; odds ratio, 1.81; 95% CI, 1.55 to 2.11; P<.001). In the Kaplan-Meier survival analysis, the cumulative probability of survival remained significantly lower in men than in women (74% vs 86%; log-rank, P<.001). The cumulative probability of survival remained significantly lower in propensity score-matched men than in women after excluding patients younger than 50 years and those who were taking angiotensin-converting enzyme inhibitor or angiotensin receptor blocker medications on admission.
Conclusion: Among patients with COVID-19 infection, men had a significantly higher mortality than did women, and this difference was not completely explained by the higher prevalence of comorbidities in men.