tetano
Editor, Senior Moderator
Mayo Clin Proc
. 2020 Nov;95(11):2467-2486.
doi: 10.1016/j.mayocp.2020.08.030. Epub 2020 Aug 31.
Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic
Robert D McBane 2nd[SUP] 1 [/SUP], Victor D Torres Roldan[SUP] 2 [/SUP], Alexander S Niven[SUP] 3 [/SUP], Rajiv K Pruthi[SUP] 4 [/SUP], Pablo Moreno Franco[SUP] 5 [/SUP], Jane A Linderbaum[SUP] 6 [/SUP], Ana I Casanegra[SUP] 7 [/SUP], Lance J Oyen[SUP] 8 [/SUP], Damon E Houghton[SUP] 7 [/SUP], Ariela L Marshall[SUP] 4 [/SUP], Narith N Ou[SUP] 8 [/SUP], Jason L Siegel[SUP] 9 [/SUP], Waldemar E Wysokinski[SUP] 7 [/SUP], Leslie J Padrnos[SUP] 10 [/SUP], Candido E Rivera[SUP] 11 [/SUP], Gayle L Flo[SUP] 6 [/SUP], Fadi E Shamoun[SUP] 12 [/SUP], Scott M Silvers[SUP] 13 [/SUP], Tarek Nayfeh[SUP] 2 [/SUP], Meritxell Urtecho[SUP] 2 [/SUP], Sahrish Shah[SUP] 2 [/SUP], Raed Benkhadra[SUP] 2 [/SUP], Samer Mohir Saadi[SUP] 2 [/SUP], Mohammed Firwana[SUP] 2 [/SUP], Tabinda Jawaid[SUP] 2 [/SUP], Mustapha Amin[SUP] 2 [/SUP], Larry J Prokop[SUP] 14 [/SUP], M Hassan Murad[SUP] 15 [/SUP]
Affiliations
Abstract
A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.
. 2020 Nov;95(11):2467-2486.
doi: 10.1016/j.mayocp.2020.08.030. Epub 2020 Aug 31.
Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic
Robert D McBane 2nd[SUP] 1 [/SUP], Victor D Torres Roldan[SUP] 2 [/SUP], Alexander S Niven[SUP] 3 [/SUP], Rajiv K Pruthi[SUP] 4 [/SUP], Pablo Moreno Franco[SUP] 5 [/SUP], Jane A Linderbaum[SUP] 6 [/SUP], Ana I Casanegra[SUP] 7 [/SUP], Lance J Oyen[SUP] 8 [/SUP], Damon E Houghton[SUP] 7 [/SUP], Ariela L Marshall[SUP] 4 [/SUP], Narith N Ou[SUP] 8 [/SUP], Jason L Siegel[SUP] 9 [/SUP], Waldemar E Wysokinski[SUP] 7 [/SUP], Leslie J Padrnos[SUP] 10 [/SUP], Candido E Rivera[SUP] 11 [/SUP], Gayle L Flo[SUP] 6 [/SUP], Fadi E Shamoun[SUP] 12 [/SUP], Scott M Silvers[SUP] 13 [/SUP], Tarek Nayfeh[SUP] 2 [/SUP], Meritxell Urtecho[SUP] 2 [/SUP], Sahrish Shah[SUP] 2 [/SUP], Raed Benkhadra[SUP] 2 [/SUP], Samer Mohir Saadi[SUP] 2 [/SUP], Mohammed Firwana[SUP] 2 [/SUP], Tabinda Jawaid[SUP] 2 [/SUP], Mustapha Amin[SUP] 2 [/SUP], Larry J Prokop[SUP] 14 [/SUP], M Hassan Murad[SUP] 15 [/SUP]
Affiliations
- PMID: 33153635
- DOI: 10.1016/j.mayocp.2020.08.030
Abstract
A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.