tetano
Editor, Senior Moderator
Math Biosci
. 2023 Dec 13:109129.
doi: 10.1016/j.mbs.2023.109129. Online ahead of print. Different routes of infection of H5N1 lead to changes in infecting time
Ishaan Gadiyar[SUP] 1 [/SUP], Hana M Dobrovolny[SUP] 2 [/SUP]
Affiliations
Influenza virus infection can result in a wide range of clinical outcomes from asymptomatic infection to severe disease and death. While there are undoubtedly many factors that contribute to the severity of disease, one possible contributing factor that needs more investigation is the route of infection. In this study, we use previously published data from cynomolgus macaques infected with A/Vietnam/1203/04 (H5N1) via either aerosol (with and without bronchoalveolar lavages (BAL)) or a combined intrabronchial, oral, and intranasal route. We fit a mathematical model of within host viral kinetics to the data and find that when the macaques are infected via the aerosol route with subsequent BAL, the infecting time is significantly lower than for the other two groups. A lower infecting time indicates that the virus spreads from cell to cell more rapidly for aerosol infection with BAL than for the combined deposition or aerosol deposition alone. This study helps elucidate the mechanism behind different infection outcomes caused by differences in routes of infection.
Keywords: Aerosol; Deposition; Infecting time; Influenza; Mathematical model.
. 2023 Dec 13:109129.
doi: 10.1016/j.mbs.2023.109129. Online ahead of print. Different routes of infection of H5N1 lead to changes in infecting time
Ishaan Gadiyar[SUP] 1 [/SUP], Hana M Dobrovolny[SUP] 2 [/SUP]
Affiliations
- PMID: 38101614
- DOI: 10.1016/j.mbs.2023.109129
Influenza virus infection can result in a wide range of clinical outcomes from asymptomatic infection to severe disease and death. While there are undoubtedly many factors that contribute to the severity of disease, one possible contributing factor that needs more investigation is the route of infection. In this study, we use previously published data from cynomolgus macaques infected with A/Vietnam/1203/04 (H5N1) via either aerosol (with and without bronchoalveolar lavages (BAL)) or a combined intrabronchial, oral, and intranasal route. We fit a mathematical model of within host viral kinetics to the data and find that when the macaques are infected via the aerosol route with subsequent BAL, the infecting time is significantly lower than for the other two groups. A lower infecting time indicates that the virus spreads from cell to cell more rapidly for aerosol infection with BAL than for the combined deposition or aerosol deposition alone. This study helps elucidate the mechanism behind different infection outcomes caused by differences in routes of infection.
Keywords: Aerosol; Deposition; Infecting time; Influenza; Mathematical model.