tetano
Editor, Senior Moderator
How long does the protection from a mother's immunization against influenza during pregnancy last for infants after they are born?
Marta C. Nunes, Ph.D., of the University of the Witwatersrand, Johannesburg, South Africa, and coauthors sought to answer that questions in an article published online by JAMA Pediatrics. It's an important question because the incidence of influenza among infants is high and illness can cause hospitalizations and death. Also, current vaccines don't work well in infants less than 6 months of age and are not licensed for use in that age group.
Infants born to women who participated in a randomized clinical trial of trivalent inactivated influenza vaccine (IIV3) when they were pregnant were followed up to determine the vaccine's efficacy against influenza and infant antibody levels during their first six months of life.
Analysis of the vaccine's efficacy included 1,026 infants born to women immunized with IIV3 and 1,023 infants born to women given placebo. The vaccine's efficacy against influenza illness was highest when infants were 8 weeks or younger at 85.6 percent but decreased as the infants grew to 25.5 percent among infants 8 to 16 weeks and to 30.3 percent among infants 16 to 24 weeks, according to the results.
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https://www.sciencedaily.com/releases/2016/07/160705120019.htm
Marta C. Nunes, Ph.D., of the University of the Witwatersrand, Johannesburg, South Africa, and coauthors sought to answer that questions in an article published online by JAMA Pediatrics. It's an important question because the incidence of influenza among infants is high and illness can cause hospitalizations and death. Also, current vaccines don't work well in infants less than 6 months of age and are not licensed for use in that age group.
Infants born to women who participated in a randomized clinical trial of trivalent inactivated influenza vaccine (IIV3) when they were pregnant were followed up to determine the vaccine's efficacy against influenza and infant antibody levels during their first six months of life.
Analysis of the vaccine's efficacy included 1,026 infants born to women immunized with IIV3 and 1,023 infants born to women given placebo. The vaccine's efficacy against influenza illness was highest when infants were 8 weeks or younger at 85.6 percent but decreased as the infants grew to 25.5 percent among infants 8 to 16 weeks and to 30.3 percent among infants 16 to 24 weeks, according to the results.
..
https://www.sciencedaily.com/releases/2016/07/160705120019.htm