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Maternal antibodies can affect fetus viability in a gender-specific manner

Emily

Emily

Editor, Senior Moderator
Reproductive immunology: Autoantibodies bring out the son
Nature Reviews Immunology 12, 398 (June 2012) | doi:10.1038/nri3238

Reproductive immunology: Autoantibodies bring out the son

Yvonne Bordon
Abstract

This paper shows how maternal antibodies can affect fetus viability in a gender-specific manner. Patients with systemic lupus erythematosus (SLE) produce antibodies specific for double-stranded DNA, and a subset of these can cross-react with and activate the N-methyl-D-aspartate receptor (NMDAR).
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