tetano
Editor, Senior Moderator
J Virol. 2015 Jun 3. pii: JVI.01132-15. [Epub ahead of print]
[h=1]Mapping of a region of the PA-X protein of influenza A virus that is important for its shut-off activity.[/h] Oishi K[SUP]1[/SUP], Yamayoshi S[SUP]2[/SUP], Kawaoka Y[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The influenza A virus PA-X comprises an N-terminal PA endonuclease domain and a C-terminal PA-X-specific domain. PA-X reduces host and viral mRNA accumulation via its endonuclease function. Here, we found that the N-terminal 15 amino acids, particularly 6 basic amino acids, in the C-terminal PA-X-specific region are important for PA-X shut-off activity. These 6 basic amino acids enabled a PA deletion mutant to suppress protein expression at a level comparable to that of wild-type PA-X.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26041295 [PubMed - as supplied by publisher]
[h=1]Mapping of a region of the PA-X protein of influenza A virus that is important for its shut-off activity.[/h] Oishi K[SUP]1[/SUP], Yamayoshi S[SUP]2[/SUP], Kawaoka Y[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The influenza A virus PA-X comprises an N-terminal PA endonuclease domain and a C-terminal PA-X-specific domain. PA-X reduces host and viral mRNA accumulation via its endonuclease function. Here, we found that the N-terminal 15 amino acids, particularly 6 basic amino acids, in the C-terminal PA-X-specific region are important for PA-X shut-off activity. These 6 basic amino acids enabled a PA deletion mutant to suppress protein expression at a level comparable to that of wild-type PA-X.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26041295 [PubMed - as supplied by publisher]