tetano
Editor, Senior Moderator
J Virol. 2013 Jul 17. [Epub ahead of print]
Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus.
Min JY, Santos C, Fitch A, Twaddle A, Toyoda Y, Depasse JV, Ghedin E, Subbarao K.
Source
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Abstract
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host-range determinant for infection of mammals. Here, we demonstrate that the E to K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tract of mice and was complete by day 6 post-inoculation. This mutation correlated with efficient replication of the virus in mice.
PMID:
23864613
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23864613
Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus.
Min JY, Santos C, Fitch A, Twaddle A, Toyoda Y, Depasse JV, Ghedin E, Subbarao K.
Source
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Abstract
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host-range determinant for infection of mammals. Here, we demonstrate that the E to K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tract of mice and was complete by day 6 post-inoculation. This mutation correlated with efficient replication of the virus in mice.
PMID:
23864613
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23864613