tetano
Editor, Senior Moderator
A research team led by Jackson Laboratory Professors Frank McKeon, Ph.D., and Wa Xian, Ph.D., reports on the role of certain lung stem cells in regenerating lungs damaged by disease.
The work, published Nov. 12 in the journal Nature, sheds light on the inner workings of the still-emerging concept of lung regeneration and points to potential therapeutic strategies that harness these lung stem cells.
"The idea that the lung can regenerate has been slow to take hold in the biomedical research community," McKeon says, "in part because of the steady decline that is seen in patients with severe lung diseases like chronic obstructive pulmonary disease (known as COPD) and pulmonary fibrosis."
Nevertheless, he notes, there are examples in humans that point to the existence of a robust system for lung regeneration. "Some survivors of acute respiratory distress syndrome, or ARDS, for example, are able to recover near-normal lung function following significant destruction of lung tissue."
Mice appear to share this capacity. Mice infected with the H1N1 influenza virus show progressive inflammation in the lung followed by outright loss of important lung cell types. Yet over several weeks, the lungs recover, revealing no signs of the previous lung injury.
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http://www.sciencedaily.com/release...cedaily+(Latest+Science+News+--+ScienceDaily)
The work, published Nov. 12 in the journal Nature, sheds light on the inner workings of the still-emerging concept of lung regeneration and points to potential therapeutic strategies that harness these lung stem cells.
"The idea that the lung can regenerate has been slow to take hold in the biomedical research community," McKeon says, "in part because of the steady decline that is seen in patients with severe lung diseases like chronic obstructive pulmonary disease (known as COPD) and pulmonary fibrosis."
Nevertheless, he notes, there are examples in humans that point to the existence of a robust system for lung regeneration. "Some survivors of acute respiratory distress syndrome, or ARDS, for example, are able to recover near-normal lung function following significant destruction of lung tissue."
Mice appear to share this capacity. Mice infected with the H1N1 influenza virus show progressive inflammation in the lung followed by outright loss of important lung cell types. Yet over several weeks, the lungs recover, revealing no signs of the previous lung injury.
...
http://www.sciencedaily.com/release...cedaily+(Latest+Science+News+--+ScienceDaily)