tetano
Editor, Senior Moderator
Vet Microbiol. 2014 Jul 12. pii: S0378-1135(14)00325-3. doi: 10.1016/j.vetmic.2014.07.002. [Epub ahead of print]
Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China.
Yu Z1, Cheng K2, Sun W3, Xin Y3, Cai J4, Ma R4, Zhao Q4, Li L3, Huang J5, Sang X3, Li X6, Zhang K7, Wang T3, Qin C7, Qian J3, Gao Y8, Xia X9.
Author information
Abstract
Avian influenza viruses (AIVs) are globally important contagions. Several domestic mammals can be infected with AIVs and may play important roles in the adaptation and transmission of these viruses in mammals, although the roles of wild mammals in the natural ecology of AIVs are not yet clear. Here, we performed a serological survey of apparently healthy Plateau pikas at Qinghai Lake in China to assess the prevalence of exposure to AIVs. Ninety-two of 293 (31%) of wild Plateau pikas possessed serum antibodies against a lowly pathogenic avian influenza (LPAI) H9N2 virus. Experimental inoculation of Plateau pikas with a LPAI H9N2 virus resulted in productive viral replication in respiratory tissues without prior adaptation. Our findings suggest that Plateau pikas represent a natural mammalian host to H9N2 AIVs and may play a role in the ongoing circulation of H9N2 viruses at Qinghai Lake in China. Surveillance for AIV infection in Plateau pika populations and other mammals that have close contact with the Plateau pikas should be considered.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Avian influenza virus; H9N2; Plateau pika; Qinghai Lake; Serological survey
PMID:
25069623
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25069623
Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China.
Yu Z1, Cheng K2, Sun W3, Xin Y3, Cai J4, Ma R4, Zhao Q4, Li L3, Huang J5, Sang X3, Li X6, Zhang K7, Wang T3, Qin C7, Qian J3, Gao Y8, Xia X9.
Author information
Abstract
Avian influenza viruses (AIVs) are globally important contagions. Several domestic mammals can be infected with AIVs and may play important roles in the adaptation and transmission of these viruses in mammals, although the roles of wild mammals in the natural ecology of AIVs are not yet clear. Here, we performed a serological survey of apparently healthy Plateau pikas at Qinghai Lake in China to assess the prevalence of exposure to AIVs. Ninety-two of 293 (31%) of wild Plateau pikas possessed serum antibodies against a lowly pathogenic avian influenza (LPAI) H9N2 virus. Experimental inoculation of Plateau pikas with a LPAI H9N2 virus resulted in productive viral replication in respiratory tissues without prior adaptation. Our findings suggest that Plateau pikas represent a natural mammalian host to H9N2 AIVs and may play a role in the ongoing circulation of H9N2 viruses at Qinghai Lake in China. Surveillance for AIV infection in Plateau pika populations and other mammals that have close contact with the Plateau pikas should be considered.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Avian influenza virus; H9N2; Plateau pika; Qinghai Lake; Serological survey
PMID:
25069623
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25069623