tetano
Editor, Senior Moderator
Clin Exp Vaccine Res. 2013 Jul;2(2):115-9. doi: 10.7774/cevr.2013.2.2.115. Epub 2013 Jul 3.
Long-term immunogenicity of the influenza vaccine at reduced intradermal and full intramuscular doses among healthy young adults.
Song JY, Cheong HJ, Noh JY, Yang TU, Seo YB, Hong KW, Kim IS, Choi WS, Kim WJ.
Source
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Asian Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea.
Abstract
PURPOSE:
To prepare for vaccine shortages under an influenza pandemic, several antigen-sparing strategies have been investigated. This study was aimed to evaluate the immunogenicity of influenza vaccine at reduced intradermal and full intramuscular dose.
MATERIALS AND METHODS:
We compared the effect of one-fifth and one-half intradermal doses to the full intramuscular dose on immunogenicity in healthy young adults, using a commercial influenza vaccine. A hemagglutination inhibition assay was used to compare the immunogenicity of the vaccination methods.
RESULTS:
The one-fifth intradermal dose (3 ?g hemagglutinin antigen, HA) was given to 30 participants, the one-half intradermal dose (7.5 ?g HA) was given to 30, and the full intramuscular dose (15 ?g HA) was given to 32. No significant differences among injection routes and dosages were seen for seroprotection rate, seroconversion rate, or geometric mean titer (GMT) fold-increase for A/H1N1, A/H3N2, and B at around 4 weeks from vaccination. Although GMT for influenza B was significantly lower at six months for the one-fifth intradermal vaccination compared to the full-dose intramuscular vaccination (32.8 vs. 63.2, p=0.048), all three groups met the Evaluation of Medicinal Products (EMA) immunogenicity criteria through 1 to 6 months.
CONCLUSION:
Intradermal administration of a one-fifth dose of influenza vaccine elicited antibody responses comparable to the intradermal one-half dose and a conventional intramuscular vaccination at 1 month post-vaccination. The immunogenicity of the one-fifth intradermal dose was sufficient to meet the requirement for the EMA criteria at six months after influenza vaccination.
KEYWORDS:
Adult, Immunogenicity, Influenza vaccines, Intradermal injections, Vaccines
PMID:
23858402
[PubMed]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23858402
Long-term immunogenicity of the influenza vaccine at reduced intradermal and full intramuscular doses among healthy young adults.
Song JY, Cheong HJ, Noh JY, Yang TU, Seo YB, Hong KW, Kim IS, Choi WS, Kim WJ.
Source
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Asian Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea.
Abstract
PURPOSE:
To prepare for vaccine shortages under an influenza pandemic, several antigen-sparing strategies have been investigated. This study was aimed to evaluate the immunogenicity of influenza vaccine at reduced intradermal and full intramuscular dose.
MATERIALS AND METHODS:
We compared the effect of one-fifth and one-half intradermal doses to the full intramuscular dose on immunogenicity in healthy young adults, using a commercial influenza vaccine. A hemagglutination inhibition assay was used to compare the immunogenicity of the vaccination methods.
RESULTS:
The one-fifth intradermal dose (3 ?g hemagglutinin antigen, HA) was given to 30 participants, the one-half intradermal dose (7.5 ?g HA) was given to 30, and the full intramuscular dose (15 ?g HA) was given to 32. No significant differences among injection routes and dosages were seen for seroprotection rate, seroconversion rate, or geometric mean titer (GMT) fold-increase for A/H1N1, A/H3N2, and B at around 4 weeks from vaccination. Although GMT for influenza B was significantly lower at six months for the one-fifth intradermal vaccination compared to the full-dose intramuscular vaccination (32.8 vs. 63.2, p=0.048), all three groups met the Evaluation of Medicinal Products (EMA) immunogenicity criteria through 1 to 6 months.
CONCLUSION:
Intradermal administration of a one-fifth dose of influenza vaccine elicited antibody responses comparable to the intradermal one-half dose and a conventional intramuscular vaccination at 1 month post-vaccination. The immunogenicity of the one-fifth intradermal dose was sufficient to meet the requirement for the EMA criteria at six months after influenza vaccination.
KEYWORDS:
Adult, Immunogenicity, Influenza vaccines, Intradermal injections, Vaccines
PMID:
23858402
[PubMed]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23858402