tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2013 Jan 30. [Epub ahead of print]
Long-term Immunogenicity of Pandemic Influenza A/H1N1 2009 Vaccine Among Healthcare Workers: Seasonal Vaccine Recipients Versus Non-recipients.
Song JY, Cheong HJ, Seo YB, Kim IS, Noh JY, Choi WS, Lee J, Jeong HW, Kee SY, Kim WJ.
Source
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Abstract
Healthcare workers (HCWs) are at great risk of influenza infection and transmission. Vaccination for seasonal influenza is routinely recommended, but this strategy should be reconsidered in a pandemic situation. Between October 2009 and September 2010, multi-center study was conducted to assess the long-term immunogenicity of the 2009 A/H1N1 monovalent influenza vaccine among HCWs compared to non-healthcare workers (NHCWs). The influence of prior seasonal influenza vaccination was also assessed with respect to the immunogenicity of pandemic H1N1 influenza vaccine. Serum hemagglutinin inhibition titers were determined pre-vaccination and then at one, six and ten months after vaccination. Of the 360 enrolled HCW subjects, 289 participated in the study up to ten months after H1N1 monovalent influenza vaccination, while 60 of 65 NHCW subjects were followed up. Seroprotection rates, seroconversion rates and geometric mean titer (GMT) ratio fulfilled the European Union's licensure criteria for influenza A/California/7/2009 (H1N1) at one month after vaccination in both the HCWs and NHCWs without any significant difference. At six months after vaccination, the seroprotection rate was more significantly lowered among the NHCWs compared to the HCWs (P < .01). Overall, post-vaccination (1, 6 and 10 months after vaccination) GMTs for A/California/7/2009 (H1N1) were significantly lower among the seasonal influenza vaccine recipients compared to the non-recipients (P < .05). In conclusion, HCWs should be encouraged to receive an annual influenza vaccination considering the risk of repeated exposure. However, prior reception of seasonal influenza vaccine showed a negative influence on immunogenicity for the pandemic 2009 A/H1N1 influenza vaccine.
PMID:
23365206
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23365206
Long-term Immunogenicity of Pandemic Influenza A/H1N1 2009 Vaccine Among Healthcare Workers: Seasonal Vaccine Recipients Versus Non-recipients.
Song JY, Cheong HJ, Seo YB, Kim IS, Noh JY, Choi WS, Lee J, Jeong HW, Kee SY, Kim WJ.
Source
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Abstract
Healthcare workers (HCWs) are at great risk of influenza infection and transmission. Vaccination for seasonal influenza is routinely recommended, but this strategy should be reconsidered in a pandemic situation. Between October 2009 and September 2010, multi-center study was conducted to assess the long-term immunogenicity of the 2009 A/H1N1 monovalent influenza vaccine among HCWs compared to non-healthcare workers (NHCWs). The influence of prior seasonal influenza vaccination was also assessed with respect to the immunogenicity of pandemic H1N1 influenza vaccine. Serum hemagglutinin inhibition titers were determined pre-vaccination and then at one, six and ten months after vaccination. Of the 360 enrolled HCW subjects, 289 participated in the study up to ten months after H1N1 monovalent influenza vaccination, while 60 of 65 NHCW subjects were followed up. Seroprotection rates, seroconversion rates and geometric mean titer (GMT) ratio fulfilled the European Union's licensure criteria for influenza A/California/7/2009 (H1N1) at one month after vaccination in both the HCWs and NHCWs without any significant difference. At six months after vaccination, the seroprotection rate was more significantly lowered among the NHCWs compared to the HCWs (P < .01). Overall, post-vaccination (1, 6 and 10 months after vaccination) GMTs for A/California/7/2009 (H1N1) were significantly lower among the seasonal influenza vaccine recipients compared to the non-recipients (P < .05). In conclusion, HCWs should be encouraged to receive an annual influenza vaccination considering the risk of repeated exposure. However, prior reception of seasonal influenza vaccine showed a negative influence on immunogenicity for the pandemic 2009 A/H1N1 influenza vaccine.
PMID:
23365206
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23365206