tetano
Editor, Senior Moderator
EClinicalMedicine. 2020 Feb 19;20:100282. doi: 10.1016/j.eclinm.2020.100282. eCollection 2020 Mar.
Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization.
Wang Q[SUP]1[/SUP], Jiang H[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Xie Y[SUP]5[/SUP], Zhang T[SUP]5[/SUP], Liu S[SUP]6[/SUP], Wu S[SUP]7[/SUP], Sun Q[SUP]8[/SUP], Song S[SUP]9[/SUP], Wang W[SUP]1[/SUP], Deng X[SUP]1[/SUP], Ren L[SUP]1[/SUP], Qin T[SUP]10[/SUP], Horby P[SUP]11[/SUP], Uyeki T[SUP]12[/SUP], Yu H[SUP]1[/SUP].
Author information
Abstract
Background:
Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.
Methods:
A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans.
Findings:
The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38?5% and 78?2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits.
Interpretation:
Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction.
Funding:
National Science Fund for Distinguished Young Scholars (grant number 81525023); Program of Shanghai Academic/Technology Research Leader (grant number 18XD1400300); National Science and Technology Major Project of China (grant numbers 2017ZX10103009-005, 2018ZX10201001-010).
? 2020 Published by Elsevier Ltd.
KEYWORDS:
CT scan; CT, computed tomography; DLCO, diffusion capacity of carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; Follow-up; GGO, ground-glass opacity; H7N9 subtype; ICU, intensive care unit; IQR, interquartile range; Prognosis; RT-PCR, reverse transcriptase polymerase chain reaction; Respiratory function tests; SD, standard deviation; SPSS, Statistical Package for Social Sciences; WHO, World Health Organization; mMRC, modified Medical Research Council
PMID:32300739PMCID:PMC7152818DOI:10.1016/j.eclinm.2020.100282
Free PMC Article
Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization.
Wang Q[SUP]1[/SUP], Jiang H[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Xie Y[SUP]5[/SUP], Zhang T[SUP]5[/SUP], Liu S[SUP]6[/SUP], Wu S[SUP]7[/SUP], Sun Q[SUP]8[/SUP], Song S[SUP]9[/SUP], Wang W[SUP]1[/SUP], Deng X[SUP]1[/SUP], Ren L[SUP]1[/SUP], Qin T[SUP]10[/SUP], Horby P[SUP]11[/SUP], Uyeki T[SUP]12[/SUP], Yu H[SUP]1[/SUP].
Author information
Abstract
Background:
Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.
Methods:
A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans.
Findings:
The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38?5% and 78?2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits.
Interpretation:
Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction.
Funding:
National Science Fund for Distinguished Young Scholars (grant number 81525023); Program of Shanghai Academic/Technology Research Leader (grant number 18XD1400300); National Science and Technology Major Project of China (grant numbers 2017ZX10103009-005, 2018ZX10201001-010).
? 2020 Published by Elsevier Ltd.
KEYWORDS:
CT scan; CT, computed tomography; DLCO, diffusion capacity of carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; Follow-up; GGO, ground-glass opacity; H7N9 subtype; ICU, intensive care unit; IQR, interquartile range; Prognosis; RT-PCR, reverse transcriptase polymerase chain reaction; Respiratory function tests; SD, standard deviation; SPSS, Statistical Package for Social Sciences; WHO, World Health Organization; mMRC, modified Medical Research Council
PMID:32300739PMCID:PMC7152818DOI:10.1016/j.eclinm.2020.100282
Free PMC Article