tetano
Editor, Senior Moderator
J Clin Virol. 2015 Sep;70:16-22. doi: 10.1016/j.jcv.2015.06.092. Epub 2015 Jun 23.
Living poultry markets in rural area: Human infection with H7N9 virus re-emerges in Zhejiang Province, China, in winter 2014.
Sun Y[SUP]1[/SUP], Wang H[SUP]2[/SUP], Lou X[SUP]1[/SUP], Mao H[SUP]1[/SUP], Yan Y[SUP]2[/SUP], Chen E[SUP]1[/SUP], Wang X[SUP]1[/SUP], Li Z[SUP]1[/SUP], Gao J[SUP]1[/SUP], Fu X[SUP]2[/SUP], Chen Z[SUP]2[/SUP], Feng Y[SUP]3[/SUP], Chen Z[SUP]1[/SUP], Zhang Y[SUP]4[/SUP].
Author information
Abstract
BACKGROUND:
Avian influenza A H7N9 virus, previously undetected in humans, has caused infections in many areas in China since February 2013. Here we report the re-emergence of a case of H7N9 in rural Jiaxing city, Zhejiang Province, in the winter of 2014.
OBJECTIVES:
To understand (1) the clinical syndrome, epidemiological and virological characteristics of this case; (2) the importance of controlling live poultry markets (LPMs) in rural areas.
STUDY DESIGN:
There is one patient and 16 contacts, including 4 family members living in the same household, and 12 medical personnel. Pharyngeal swabs and serum samples were collected from the patient and her contacts. Environment samples were also obtained from the local LPMs. We conducted detailed clinical and epidemiological investigations and laboratory work, including viral RNA extraction, RT-PCR detection and sequencing. Characteristic and phylogenetic analyses were performed using the obtained sequences.
RESULTS:
H7N9s were detected in environmental samples collected in LPMs in Jiaxing, Zhejiang. Unknown mutations were discovered in amino acids in the sample from the patient. The strain from the patient was in a clade different from isolates obtained in 2013 in phylogenetic trees of HA, NA and PB2.
CONCLUSIONS:
A severe case of H7N9 was identified in early winter, 2014. Epidemiological and clinical tests were consistent with patterns reported previously, while laboratory findings showed the virus to be different. Live poultry markets in rural Zhejiang Province are in need of closer supervision and enhanced management.
Copyright ? 2015 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Avian influenza; H7N9; Live poultry market; Rural area
PMID: 26305813 [PubMed - in process] Free full text
Living poultry markets in rural area: Human infection with H7N9 virus re-emerges in Zhejiang Province, China, in winter 2014.
Sun Y[SUP]1[/SUP], Wang H[SUP]2[/SUP], Lou X[SUP]1[/SUP], Mao H[SUP]1[/SUP], Yan Y[SUP]2[/SUP], Chen E[SUP]1[/SUP], Wang X[SUP]1[/SUP], Li Z[SUP]1[/SUP], Gao J[SUP]1[/SUP], Fu X[SUP]2[/SUP], Chen Z[SUP]2[/SUP], Feng Y[SUP]3[/SUP], Chen Z[SUP]1[/SUP], Zhang Y[SUP]4[/SUP].
Author information
Abstract
BACKGROUND:
Avian influenza A H7N9 virus, previously undetected in humans, has caused infections in many areas in China since February 2013. Here we report the re-emergence of a case of H7N9 in rural Jiaxing city, Zhejiang Province, in the winter of 2014.
OBJECTIVES:
To understand (1) the clinical syndrome, epidemiological and virological characteristics of this case; (2) the importance of controlling live poultry markets (LPMs) in rural areas.
STUDY DESIGN:
There is one patient and 16 contacts, including 4 family members living in the same household, and 12 medical personnel. Pharyngeal swabs and serum samples were collected from the patient and her contacts. Environment samples were also obtained from the local LPMs. We conducted detailed clinical and epidemiological investigations and laboratory work, including viral RNA extraction, RT-PCR detection and sequencing. Characteristic and phylogenetic analyses were performed using the obtained sequences.
RESULTS:
H7N9s were detected in environmental samples collected in LPMs in Jiaxing, Zhejiang. Unknown mutations were discovered in amino acids in the sample from the patient. The strain from the patient was in a clade different from isolates obtained in 2013 in phylogenetic trees of HA, NA and PB2.
CONCLUSIONS:
A severe case of H7N9 was identified in early winter, 2014. Epidemiological and clinical tests were consistent with patterns reported previously, while laboratory findings showed the virus to be different. Live poultry markets in rural Zhejiang Province are in need of closer supervision and enhanced management.
Copyright ? 2015 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Avian influenza; H7N9; Live poultry market; Rural area
PMID: 26305813 [PubMed - in process] Free full text
Last edited: