tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2011 Sep 23. doi: 10.1111/j.1750-2659.2011.00287.x. [Epub ahead of print]
Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Papic N, Pangercic A, Vargovic M, Barsic B, Vince A, Kuzman I.
Source
Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Adult Intensive Care and Neuroinfection, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Urinary Tract Infections, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Acute Respiratory Infections, University Hospital for Infectious Diseases, Zagreb, Croatia.
Abstract
Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00287.x. Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
? 2011 Blackwell Publishing Ltd.
PMID:
21951624
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21951624
Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Papic N, Pangercic A, Vargovic M, Barsic B, Vince A, Kuzman I.
Source
Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Adult Intensive Care and Neuroinfection, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Urinary Tract Infections, University Hospital for Infectious Diseases, Zagreb, Croatia Department of Acute Respiratory Infections, University Hospital for Infectious Diseases, Zagreb, Croatia.
Abstract
Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00287.x. Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
? 2011 Blackwell Publishing Ltd.
PMID:
21951624
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21951624