tetano
Editor, Senior Moderator
J Infect Dis. 2014 Dec 11. pii: jiu804. [Epub ahead of print]
[h=1]Live-attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear.[/h] Mina MJ[SUP]1[/SUP], Klugman KP[SUP]2[/SUP], Rosch JW[SUP]3[/SUP], McCullers JA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Infection with influenza A virus (IAV) increases susceptibility to respiratory bacterial infections, resulting in increased bacterial carriage and complications such acute otitis media, pneumonia, bacteremia and meningitis. Recently, vaccination with live attenuated influenza virus (LAIV) was reported to enhance subclinical bacterial colonization within the nasopharynx, similar to IAV. Although LAIV does not predispose to bacterial pneumonia, whether it may alter bacterial transmigration towards the middle ear, where it could have clinically relevant implications, has not been investigated.
[h=4]METHODS:[/h] Balb/c mice received LAIV or PBS one or seven days prior to, or during pneumococcal colonization with either of two clinical isolates, 19F or 7F. Middle ear bacterial titers were monitored daily via in-vivo imaging.
[h=4]RESULTS:[/h] LAIV increased bacterial transmigration to and persistence within the middle ear. When colonization followed LAIV inoculation, a minimum LAIV incubation period of four days was required before bacterial transmigration commenced.
[h=4]CONCLUSIONS:[/h] While LAIV vaccination is safe and effective at reducing IAV and influenza-bacterial coinfections, LAIV may increase bacterial transmigration to the middle ear and could thus increase risk of clinically relevant acute otitis media. These data warrant further investigations into interactions between live attenuated viruses and naturally colonizing bacterial pathogens.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25505300 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25505300
[h=1]Live-attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear.[/h] Mina MJ[SUP]1[/SUP], Klugman KP[SUP]2[/SUP], Rosch JW[SUP]3[/SUP], McCullers JA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Infection with influenza A virus (IAV) increases susceptibility to respiratory bacterial infections, resulting in increased bacterial carriage and complications such acute otitis media, pneumonia, bacteremia and meningitis. Recently, vaccination with live attenuated influenza virus (LAIV) was reported to enhance subclinical bacterial colonization within the nasopharynx, similar to IAV. Although LAIV does not predispose to bacterial pneumonia, whether it may alter bacterial transmigration towards the middle ear, where it could have clinically relevant implications, has not been investigated.
[h=4]METHODS:[/h] Balb/c mice received LAIV or PBS one or seven days prior to, or during pneumococcal colonization with either of two clinical isolates, 19F or 7F. Middle ear bacterial titers were monitored daily via in-vivo imaging.
[h=4]RESULTS:[/h] LAIV increased bacterial transmigration to and persistence within the middle ear. When colonization followed LAIV inoculation, a minimum LAIV incubation period of four days was required before bacterial transmigration commenced.
[h=4]CONCLUSIONS:[/h] While LAIV vaccination is safe and effective at reducing IAV and influenza-bacterial coinfections, LAIV may increase bacterial transmigration to the middle ear and could thus increase risk of clinically relevant acute otitis media. These data warrant further investigations into interactions between live attenuated viruses and naturally colonizing bacterial pathogens.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25505300 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25505300