tetano
Editor, Senior Moderator
J Infect Dis. 2014 Aug 26. pii: jiu458. [Epub ahead of print]
Live Attenuated and Inactivated Influenza Vaccines in Children.
Ilyushina NA1, Haynes BC1, Hoen AG2, Khalenkov AM1, Housman ML3, Brown EP4, Ackerman ME4, Treanor JJ5, Luke CJ6, Subbarao K6, Wright PF1.
Author information
Abstract
BACKGROUND:
Live, attenuated (LAIV) and inactivated influenza (IIV) vaccines are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure.
METHODS:
Fifteen children received IIV followed by LAIV, 13 an initial dose of LAIV, and 11 a 2nd dose of LAIV. The studies were done during the falls of 2009-2010 with the same seasonal vaccine (A/California/07/09 (H1N1), A/Perth/16/09 (H3N2), B/Brisbane/60/08).
RESULTS:
Twenty-eight of 39 possible influenza viral strains were recovered after the initial dose of LAIV. When LAIV followed IIV 21/45 viral strains were identified. When compared to primary LAIV infection the decreased frequency of shedding with the IIV-LAIV schedule was significant (P=0.023). With LAIV-LAIV, the fewest viral strains were recovered, 3/33 - numbers significantly lower (P<0.001) than shedding after initial LAIV and after IIV-LAIV(P<0.001). Serum HAI antibody responses were more frequent after IIV than LAIV (P=0.02). In contrast, more mucosal IgA responses were seen with LAIV.
CONCLUSIONS:
LAIV priming induces greater inhibition of virus recovery on LAIV challenge than IIV priming. The correlate(s) of protection are the subject of ongoing analysis.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25165161
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25165161
Live Attenuated and Inactivated Influenza Vaccines in Children.
Ilyushina NA1, Haynes BC1, Hoen AG2, Khalenkov AM1, Housman ML3, Brown EP4, Ackerman ME4, Treanor JJ5, Luke CJ6, Subbarao K6, Wright PF1.
Author information
Abstract
BACKGROUND:
Live, attenuated (LAIV) and inactivated influenza (IIV) vaccines are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure.
METHODS:
Fifteen children received IIV followed by LAIV, 13 an initial dose of LAIV, and 11 a 2nd dose of LAIV. The studies were done during the falls of 2009-2010 with the same seasonal vaccine (A/California/07/09 (H1N1), A/Perth/16/09 (H3N2), B/Brisbane/60/08).
RESULTS:
Twenty-eight of 39 possible influenza viral strains were recovered after the initial dose of LAIV. When LAIV followed IIV 21/45 viral strains were identified. When compared to primary LAIV infection the decreased frequency of shedding with the IIV-LAIV schedule was significant (P=0.023). With LAIV-LAIV, the fewest viral strains were recovered, 3/33 - numbers significantly lower (P<0.001) than shedding after initial LAIV and after IIV-LAIV(P<0.001). Serum HAI antibody responses were more frequent after IIV than LAIV (P=0.02). In contrast, more mucosal IgA responses were seen with LAIV.
CONCLUSIONS:
LAIV priming induces greater inhibition of virus recovery on LAIV challenge than IIV priming. The correlate(s) of protection are the subject of ongoing analysis.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25165161
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25165161