tetano
Editor, Senior Moderator
Life Sci
. 2023 Mar 10;121569.
doi: 10.1016/j.lfs.2023.121569. Online ahead of print.
Anti-cancer effect of COVID-19 vaccines in 4T1 mice models
Negar Deldadeh[SUP] 1 [/SUP], Shahpar Haghighat[SUP] 2 [/SUP], Zahra Omidi[SUP] 2 [/SUP], Ramin Sarrami-Foroushani[SUP] 3 [/SUP], Alireza Madjid Ansari[SUP] 4 [/SUP], Hassan Sanati[SUP] 3 [/SUP], Azadeh Azizi[SUP] 4 [/SUP], Farid Zayeri[SUP] 5 [/SUP], Flora Forouzesh[SUP] 6 [/SUP], Teunis B H Geijtenbeek[SUP] 7 [/SUP], Mohammad Amin Javidi[SUP] 8 [/SUP]
Affiliations
Abstract
Aims: Without any doubt, vaccination was the best choice for Coronavirus disease 2019 (COVID-19) pandemic control. According to the American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO), people with cancer or a history of cancer have a higher risk of dying from Covid-19 than ordinary people; hence, they should be considered a high-priority group for vaccination. On the other hand, the effect of the Covid-19 vaccination on cancer is not transparent enough. This study is one of the first in vivo studies that try to show the impact of Sinopharm (S) and AstraZeneca (A) vaccines on breast cancer, the most common cancer among women worldwide.
Materials and methods: Vaccination was performed with one and two doses of Sinopharm (S1/S2) or AstraZeneca (A1/A2) on the 4T1 triple-negative breast cancer (TNBC) mice model. The tumor size and body weight of mice were monitored every two days. After one month, mice were euthanized, and the existence of Tumor-infiltrating lymphocytes (TILs) and expression of the important markers in the tumor site was assessed. Metastasis in the vital organs was also investigated.
Key findings: Strikingly, all of the vaccinated mice showed a decrease in tumor size and this decrease was highest after two vaccinations. Moreover, we observed more TILs in the tumor after vaccination. Vaccinated mice demonstrated a decrease in the expression of tumor markers (VEGF, Ki-67, MMP-2/9), CD4/CD8 ratio, and metastasis to the vital organs.
Significance: Our results strongly suggest that COVID-19 vaccinations decrease tumor growth and metastasis.
Keywords: Metastasis; SARS-CoV-2; TNBC; Tumor size.
. 2023 Mar 10;121569.
doi: 10.1016/j.lfs.2023.121569. Online ahead of print.
Anti-cancer effect of COVID-19 vaccines in 4T1 mice models
Negar Deldadeh[SUP] 1 [/SUP], Shahpar Haghighat[SUP] 2 [/SUP], Zahra Omidi[SUP] 2 [/SUP], Ramin Sarrami-Foroushani[SUP] 3 [/SUP], Alireza Madjid Ansari[SUP] 4 [/SUP], Hassan Sanati[SUP] 3 [/SUP], Azadeh Azizi[SUP] 4 [/SUP], Farid Zayeri[SUP] 5 [/SUP], Flora Forouzesh[SUP] 6 [/SUP], Teunis B H Geijtenbeek[SUP] 7 [/SUP], Mohammad Amin Javidi[SUP] 8 [/SUP]
Affiliations
- PMID: 36907328
- DOI: 10.1016/j.lfs.2023.121569
Abstract
Aims: Without any doubt, vaccination was the best choice for Coronavirus disease 2019 (COVID-19) pandemic control. According to the American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO), people with cancer or a history of cancer have a higher risk of dying from Covid-19 than ordinary people; hence, they should be considered a high-priority group for vaccination. On the other hand, the effect of the Covid-19 vaccination on cancer is not transparent enough. This study is one of the first in vivo studies that try to show the impact of Sinopharm (S) and AstraZeneca (A) vaccines on breast cancer, the most common cancer among women worldwide.
Materials and methods: Vaccination was performed with one and two doses of Sinopharm (S1/S2) or AstraZeneca (A1/A2) on the 4T1 triple-negative breast cancer (TNBC) mice model. The tumor size and body weight of mice were monitored every two days. After one month, mice were euthanized, and the existence of Tumor-infiltrating lymphocytes (TILs) and expression of the important markers in the tumor site was assessed. Metastasis in the vital organs was also investigated.
Key findings: Strikingly, all of the vaccinated mice showed a decrease in tumor size and this decrease was highest after two vaccinations. Moreover, we observed more TILs in the tumor after vaccination. Vaccinated mice demonstrated a decrease in the expression of tumor markers (VEGF, Ki-67, MMP-2/9), CD4/CD8 ratio, and metastasis to the vital organs.
Significance: Our results strongly suggest that COVID-19 vaccinations decrease tumor growth and metastasis.
Keywords: Metastasis; SARS-CoV-2; TNBC; Tumor size.