tetano
Editor, Senior Moderator
Life (Basel)
. 2021 Apr 1;11(4):298.
doi: 10.3390/life11040298.
Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
Daniele Focosi[SUP] 1 [/SUP], Angelo Genoni[SUP] 2 [/SUP], Ersilia Lucenteforte[SUP] 3 [/SUP], Silvia Tillati[SUP] 3 [/SUP], Antonio Tamborini[SUP] 4 [/SUP], Pietro Giorgio Spezia[SUP] 5 [/SUP], Lorenzo Azzi[SUP] 2 6 [/SUP], Andreina Baj[SUP] 2 4 [/SUP], Fabrizio Maggi[SUP] 2 4 [/SUP]
Affiliations
Abstract
Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization's (WHO) clinical severity score ? 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.
Keywords: 229E; COVID-19; HKU1; NL63; OC43; SARS-CoV-2; convalescent plasma; neutralizing antibody.
. 2021 Apr 1;11(4):298.
doi: 10.3390/life11040298.
Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin
Daniele Focosi[SUP] 1 [/SUP], Angelo Genoni[SUP] 2 [/SUP], Ersilia Lucenteforte[SUP] 3 [/SUP], Silvia Tillati[SUP] 3 [/SUP], Antonio Tamborini[SUP] 4 [/SUP], Pietro Giorgio Spezia[SUP] 5 [/SUP], Lorenzo Azzi[SUP] 2 6 [/SUP], Andreina Baj[SUP] 2 4 [/SUP], Fabrizio Maggi[SUP] 2 4 [/SUP]
Affiliations
- PMID: 33915711
- DOI: 10.3390/life11040298
Abstract
Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization's (WHO) clinical severity score ? 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.
Keywords: 229E; COVID-19; HKU1; NL63; OC43; SARS-CoV-2; convalescent plasma; neutralizing antibody.