tetano
Editor, Senior Moderator
Leukemia
. 2020 Jun 11.
doi: 10.1038/s41375-020-0910-1. Online ahead of print.
Hematological Features of Persons With COVID-19
Qiubai Li[SUP] 1 [/SUP], Yulin Cao[SUP] 2 [/SUP], Lei Chen[SUP] 2 [/SUP], Di Wu[SUP] 2 [/SUP], Jianming Yu[SUP] 2 [/SUP], Hongxiang Wang[SUP] 3 [/SUP], Wenjuan He[SUP] 2 [/SUP], Li Chen[SUP] 3 [/SUP], Fang Dong[SUP] 4 [/SUP], Weiqun Chen[SUP] 5 [/SUP], Wenlan Chen[SUP] 2 [/SUP], Lei Li[SUP] 6 [/SUP], Qijie Ran[SUP] 7 [/SUP], Qiaomei Liu[SUP] 8 [/SUP], Wenxiang Ren[SUP] 2 [/SUP], Fei Gao[SUP] 2 [/SUP], Zhichao Chen[SUP] 9 [/SUP], Robert Peter Gale[SUP] 10 [/SUP], Yu Hu[SUP] 11 [/SUP]
Affiliations
Abstract
We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P = 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82]; P = 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Δ fibrinogen (OR = 6.45 [1.31, 31.69]; P = 0.022), Δ platelets (OR = 0.95 [0.90-0.99]; P = 0.029), Δ C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18]; P = 0.037), and Δ lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06]; P = 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.
. 2020 Jun 11.
doi: 10.1038/s41375-020-0910-1. Online ahead of print.
Hematological Features of Persons With COVID-19
Qiubai Li[SUP] 1 [/SUP], Yulin Cao[SUP] 2 [/SUP], Lei Chen[SUP] 2 [/SUP], Di Wu[SUP] 2 [/SUP], Jianming Yu[SUP] 2 [/SUP], Hongxiang Wang[SUP] 3 [/SUP], Wenjuan He[SUP] 2 [/SUP], Li Chen[SUP] 3 [/SUP], Fang Dong[SUP] 4 [/SUP], Weiqun Chen[SUP] 5 [/SUP], Wenlan Chen[SUP] 2 [/SUP], Lei Li[SUP] 6 [/SUP], Qijie Ran[SUP] 7 [/SUP], Qiaomei Liu[SUP] 8 [/SUP], Wenxiang Ren[SUP] 2 [/SUP], Fei Gao[SUP] 2 [/SUP], Zhichao Chen[SUP] 9 [/SUP], Robert Peter Gale[SUP] 10 [/SUP], Yu Hu[SUP] 11 [/SUP]
Affiliations
- PMID: 32528042
- DOI: 10.1038/s41375-020-0910-1
Abstract
We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P = 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82]; P = 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Δ fibrinogen (OR = 6.45 [1.31, 31.69]; P = 0.022), Δ platelets (OR = 0.95 [0.90-0.99]; P = 0.029), Δ C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18]; P = 0.037), and Δ lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06]; P = 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.