Mary Wilson
Well-known member
First published: 27 January 2025
https://doi.org/10.1002/mef2.70012
Yi Wang, Xiaoxia Wang, Xiong Zhu, Guogang Xu
Dear Editor,
Most individuals with COVID-19, caused by SARS-CoV-2 infection, experience asymptomatic or mild-to-moderate symptoms, while a minority of patients may deteriorate to severe illness or fatal outcomes [1]. Severe COVID-19 can lead to critical complications, including respiratory distress and increased mortality rates [2]. One such complication is the development of “white lung” on chest radiographs (e.g., X-ray), characterized by extensive inflammation and fluid accumulation affecting 70%–80% of the lung area [3]. The appearance of white lung signals a critical stage in COVID-19 patients, profoundly impairing lung function, often requiring mechanical ventilation and ICU admission, and substantially increasing mortality risk [1, 2]. Despite extensive research into the pathophysiology of COVID-19, the mechanisms underlying “white lung” remain poorly understood.
Here, we performed single-cell RNA sequencing analysis of bronchoalveolar lavage fluid (BALF) to characterize the pathophysiology of “white lung” in COVID-19 (Figure 1A). BALF samples were collected from 16 patients ...
https://onlinelibrary.wiley.com/doi/10.1002/mef2.70012
https://doi.org/10.1002/mef2.70012
Yi Wang, Xiaoxia Wang, Xiong Zhu, Guogang Xu
Dear Editor,
Most individuals with COVID-19, caused by SARS-CoV-2 infection, experience asymptomatic or mild-to-moderate symptoms, while a minority of patients may deteriorate to severe illness or fatal outcomes [1]. Severe COVID-19 can lead to critical complications, including respiratory distress and increased mortality rates [2]. One such complication is the development of “white lung” on chest radiographs (e.g., X-ray), characterized by extensive inflammation and fluid accumulation affecting 70%–80% of the lung area [3]. The appearance of white lung signals a critical stage in COVID-19 patients, profoundly impairing lung function, often requiring mechanical ventilation and ICU admission, and substantially increasing mortality risk [1, 2]. Despite extensive research into the pathophysiology of COVID-19, the mechanisms underlying “white lung” remain poorly understood.
Here, we performed single-cell RNA sequencing analysis of bronchoalveolar lavage fluid (BALF) to characterize the pathophysiology of “white lung” in COVID-19 (Figure 1A). BALF samples were collected from 16 patients ...
https://onlinelibrary.wiley.com/doi/10.1002/mef2.70012