Lethal interaction of ubiquitous insecticide carriers with virus

[Emily]

http://www.sciencemag.org/content/192/4246/1351.abstract

Science 25 June 1976:
Vol. 192 no. 4246 pp. 1351-1353
DOI: 10.1126/science.179146
[h=1]Lethal interaction of ubiquitous insecticide carriers with virus[/h]

• JF Crocker,
• RL Ozere,
• SH Safe,
• SC Digout,
• KR Rozee,
• O Hutzinger

• Abstract

Large quantities of presumably nontoxic petroleum oil by-products are introduced into the environment as pesticide dispersal agents and emulsifiers. An increase in viral lethality with a concomitant influence on the liver and central nervous system occurs in young mice previously primed with such chemicals.

http://aem.asm.org/content/40/4/787.short

[h=1]Appl. Environ. Microbiol. October 1980 vol. 40 no. 4 787-793

Emulsifiers that enhance susceptibility to virus infection: increased virus penetration and reduced interferon response.[/h]

• S H Lee,
• M Laltoo,
• J F Crocker and
• K R Rozee

[h=2]ABSTRACT[/h] An emulsifier which had an environmental relationship to Reye's syndrome, when used to treated L-929 cultures, was shown to increase the rate of encephalomyocarditis virus penetration and uncoating while having no effect on the attachment of virus or on the replication of infectious ribonucleic acid. This treatment also rendered L-929 cells unable to respond normally to interferon inducers and reversed an already established interferon antiviral state. It is proposed that one or more of these actions result in the cellular enhancement of virus susceptibility.