Gert van der Hoek
In Memoriam - Editor, Senior Moderator
Published:June 15, 2020
Children and adolescents with COVID-19 fare considerably better than adults, with mortality rates in paediatric patients (age <18 years) of less than 1% reported in early studies.
[SUP]1[/SUP]
The most common clinical features in children described in the literature are fever, dry cough, and pneumonia.
[SUP]2[/SUP]
However, multisystem involvement is increasingly being recognised, including the development of hyperinflammatory shock.
Acute kidney injury has been reported in adult patients with COVID-19, with a high prevalence across inpatient admissions (≤7%) and admissions to adult intensive care units (ICUs; ≤23%), as first reported in Wuhan, China.
[SUP]3[/SUP]
In adult patients with COVID-19, acute kidney injury is related to an increased mortality risk, even after adjustment for age, sex, and comorbidities.
[SUP]4[/SUP]
In addition, a large proportion of adults have proteinuria (44%) and haematuria (27%) at presentation, despite an elevated serum creatinine prevalence of only 16%.
[SUP]4[/SUP]
Qui and colleagues
[SUP]2[/SUP]
described the characteristics of 36 hospitalised paediatric patients (age 0–16 years) with COVID-19 in China and none were reported to have renal dysfunction, as defined by serum creatinine greater than 110 μmol/L or serum urea greater than 7 mmol/L.
Here, we present the findings of 52 paediatric patients (age 0–16 years) admitted to Great Ormond Street Hospital for Children NHS Foundation Trust (London, UK) since March 25, 2020, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, diagnosed by either a positive PCR result or seropositivity (appendix p 1).
Children and adolescents with COVID-19 fare considerably better than adults, with mortality rates in paediatric patients (age <18 years) of less than 1% reported in early studies.
[SUP]1[/SUP]
The most common clinical features in children described in the literature are fever, dry cough, and pneumonia.
[SUP]2[/SUP]
However, multisystem involvement is increasingly being recognised, including the development of hyperinflammatory shock.
Acute kidney injury has been reported in adult patients with COVID-19, with a high prevalence across inpatient admissions (≤7%) and admissions to adult intensive care units (ICUs; ≤23%), as first reported in Wuhan, China.
[SUP]3[/SUP]
In adult patients with COVID-19, acute kidney injury is related to an increased mortality risk, even after adjustment for age, sex, and comorbidities.
[SUP]4[/SUP]
In addition, a large proportion of adults have proteinuria (44%) and haematuria (27%) at presentation, despite an elevated serum creatinine prevalence of only 16%.
[SUP]4[/SUP]
Qui and colleagues
[SUP]2[/SUP]
described the characteristics of 36 hospitalised paediatric patients (age 0–16 years) with COVID-19 in China and none were reported to have renal dysfunction, as defined by serum creatinine greater than 110 μmol/L or serum urea greater than 7 mmol/L.
Here, we present the findings of 52 paediatric patients (age 0–16 years) admitted to Great Ormond Street Hospital for Children NHS Foundation Trust (London, UK) since March 25, 2020, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, diagnosed by either a positive PCR result or seropositivity (appendix p 1).