tetano
Editor, Senior Moderator
Lancet Reg Health West Pac
. 2022 Mar;20:100365.
doi: 10.1016/j.lanwpc.2021.100365. Epub 2022 Jan 2.
Comparison of patient characteristics and in-hospital mortality between patients with COVID-19 in 2020 and those with influenza in 2017-2020: a multicenter, retrospective cohort study in Japan
Yuta Taniguchi[SUP] 1 2 [/SUP], Toshiki Kuno[SUP] 3 [/SUP], Jun Komiyama[SUP] 1 [/SUP], Motohiko Adomi[SUP] 1 [/SUP], Toshiki Suzuki[SUP] 4 [/SUP], Toshikazu Abe[SUP] 2 5 [/SUP], Miho Ishimaru[SUP] 6 [/SUP], Atsushi Miyawaki[SUP] 2 7 8 [/SUP], Makoto Saito[SUP] 9 [/SUP], Hiroyuki Ohbe[SUP] 10 [/SUP], Yoshihisa Miyamoto[SUP] 11 [/SUP], Shinobu Imai[SUP] 12 [/SUP], Tadashi Kamio[SUP] 13 [/SUP], Nanako Tamiya[SUP] 2 6 [/SUP], Masao Iwagami[SUP] 2 6 14 [/SUP]
Affiliations
Abstract
Background: COVID-19 has worse mortality than influenza in American and European studies, but evidence from the Western Pacific region is scarce.
Methods: Using a large-scale multicenter inpatient claims data in Japan, we identified individuals hospitalised with COVID-19 in 2020 or influenza in 2017-2020. We compared patient characteristics, supportive care, and in-hospital mortality, with multivariable logistic regression analyses for in-hospital mortality overall, by age group, and among patients with mechanical ventilation.
Findings: We identified 16,790 COVID-19 patients and 27,870 influenza patients, with the different age distribution (peak at 70-89 years in COVID-19 vs. bimodal peaks at 0-9 and 80-89 years in influenza). On admission, the use of mechanical ventilation was similar in both groups (1·4% vs. 1·4%) but higher in the COVID-19 group (3·3% vs. 2·5%; p<0·0001) during the entire hospitalisation. The crude in-hospital mortality was 5·1% (856/16,790) for COVID-19 and 2·8% (791/27,870) for influenza. Adjusted for potential confounders, the in-hospital mortality was higher for COVID-19 than for influenza (adjusted odds ratio [aOR] 1·83, 95% confidence interval [CI] 1·64-2·04). In age-stratified analyses, the aOR (95%CI) were 0·78 (0·56-1·08) and 2·05 (1·83-2·30) in patients aged 20-69 years and ≥70 years, respectively (p-for-interaction<0·0001). Among patients with mechanical ventilation, the aOR was 0·79 (0·59-1·05).
Interpretation: Patients hospitalised with COVID-19 in Japan were more likely to die than those with influenza. However, this was mainly driven by findings in older people, and there was no difference once mechanical ventilation was started.
Funding: Ministry of Health, Labour and Welfare of Japan (21AA2007).
. 2022 Mar;20:100365.
doi: 10.1016/j.lanwpc.2021.100365. Epub 2022 Jan 2.
Comparison of patient characteristics and in-hospital mortality between patients with COVID-19 in 2020 and those with influenza in 2017-2020: a multicenter, retrospective cohort study in Japan
Yuta Taniguchi[SUP] 1 2 [/SUP], Toshiki Kuno[SUP] 3 [/SUP], Jun Komiyama[SUP] 1 [/SUP], Motohiko Adomi[SUP] 1 [/SUP], Toshiki Suzuki[SUP] 4 [/SUP], Toshikazu Abe[SUP] 2 5 [/SUP], Miho Ishimaru[SUP] 6 [/SUP], Atsushi Miyawaki[SUP] 2 7 8 [/SUP], Makoto Saito[SUP] 9 [/SUP], Hiroyuki Ohbe[SUP] 10 [/SUP], Yoshihisa Miyamoto[SUP] 11 [/SUP], Shinobu Imai[SUP] 12 [/SUP], Tadashi Kamio[SUP] 13 [/SUP], Nanako Tamiya[SUP] 2 6 [/SUP], Masao Iwagami[SUP] 2 6 14 [/SUP]
Affiliations
- PMID: 35005672
- PMCID: PMC8720491
- DOI: 10.1016/j.lanwpc.2021.100365
Abstract
Background: COVID-19 has worse mortality than influenza in American and European studies, but evidence from the Western Pacific region is scarce.
Methods: Using a large-scale multicenter inpatient claims data in Japan, we identified individuals hospitalised with COVID-19 in 2020 or influenza in 2017-2020. We compared patient characteristics, supportive care, and in-hospital mortality, with multivariable logistic regression analyses for in-hospital mortality overall, by age group, and among patients with mechanical ventilation.
Findings: We identified 16,790 COVID-19 patients and 27,870 influenza patients, with the different age distribution (peak at 70-89 years in COVID-19 vs. bimodal peaks at 0-9 and 80-89 years in influenza). On admission, the use of mechanical ventilation was similar in both groups (1·4% vs. 1·4%) but higher in the COVID-19 group (3·3% vs. 2·5%; p<0·0001) during the entire hospitalisation. The crude in-hospital mortality was 5·1% (856/16,790) for COVID-19 and 2·8% (791/27,870) for influenza. Adjusted for potential confounders, the in-hospital mortality was higher for COVID-19 than for influenza (adjusted odds ratio [aOR] 1·83, 95% confidence interval [CI] 1·64-2·04). In age-stratified analyses, the aOR (95%CI) were 0·78 (0·56-1·08) and 2·05 (1·83-2·30) in patients aged 20-69 years and ≥70 years, respectively (p-for-interaction<0·0001). Among patients with mechanical ventilation, the aOR was 0·79 (0·59-1·05).
Interpretation: Patients hospitalised with COVID-19 in Japan were more likely to die than those with influenza. However, this was mainly driven by findings in older people, and there was no difference once mechanical ventilation was started.
Funding: Ministry of Health, Labour and Welfare of Japan (21AA2007).
