tetano
Editor, Senior Moderator
Lancet Reg Health Am
. 2022 Nov;15:100348.
doi: 10.1016/j.lana.2022.100348. Epub 2022 Aug 18.
The clinical and genomic epidemiology of seasonal human coronaviruses in congregate homeless shelter settings: A repeated cross-sectional study
Eric J Chow[SUP] 1 [/SUP], Amanda M Casto[SUP] 1 2 [/SUP], Julia H Rogers[SUP] 1 3 [/SUP], Pavitra Roychoudhury[SUP] 2 4 [/SUP], Peter D Han[SUP] 5 6 [/SUP], Hong Xie[SUP] 4 [/SUP], Margaret G Mills[SUP] 4 [/SUP], Tien V Nguyen[SUP] 4 [/SUP], Brian Pfau[SUP] 5 6 [/SUP], Sarah N Cox[SUP] 1 3 [/SUP], Caitlin R Wolf[SUP] 1 [/SUP], James P Hughes[SUP] 2 7 [/SUP], Timothy M Uyeki[SUP] 8 [/SUP], Melissa A Rolfes[SUP] 8 [/SUP], Emily Mosites[SUP] 9 [/SUP], M Mia Shim[SUP] 10 11 [/SUP], Jeffrey S Duchin[SUP] 1 10 [/SUP], Nancy Sugg[SUP] 11 [/SUP], Lea A Starita[SUP] 2 4 [/SUP], Janet A Englund[SUP] 12 [/SUP], Helen Y Chu[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The circulation of respiratory viruses poses a significant health risk among those residing in congregate settings. Data are limited on seasonal human coronavirus (HCoV) infections in homeless shelter settings.
Methods: We analysed data from a clinical trial and SARS-CoV-2 surveillance study at 23 homeless shelter sites in King County, Washington between October 2019-May 2021. Eligible participants were shelter residents aged ≥3 months with acute respiratory illness. We collected enrolment data and nasal samples for respiratory virus testing using multiplex RT-PCR platform including HCoV. Beginning April 1, 2020, eligibility expanded to shelter residents and staff regardless of symptoms. HCoV species was determined by RT-PCR with species-specific primers, OpenArray assay or genomic sequencing for samples with an OpenArray relative cycle threshold <22.
Findings: Of the 14,464 samples from 3281 participants between October 2019-May 2021, 107 were positive for HCoV from 90 participants (median age 40 years, range: 0·9-81 years, 38% female). HCoV-HKU1 was the most common species identified before and after community-wide mitigation. No HCoV-positive samples were identified between May 2020-December 2020. Adults aged ≥50 years had the highest detection of HCoV (11%) among virus-positive samples among all age-groups. Species and sequence data showed diversity between and within HCoV species over the study period.
Interpretation: HCoV infections occurred in all congregate homeless shelter site age-groups with the greatest proportion among those aged ≥50 years. Species and sequencing data highlight the complexity of HCoV epidemiology within and between shelters sites.
Funding: Gates Ventures, Centers for Disease Control and Prevention, National Institute of Health.
Keywords: Homeless shelters; Homelessness; Human coronavirus; Respiratory viral infections.
. 2022 Nov;15:100348.
doi: 10.1016/j.lana.2022.100348. Epub 2022 Aug 18.
The clinical and genomic epidemiology of seasonal human coronaviruses in congregate homeless shelter settings: A repeated cross-sectional study
Eric J Chow[SUP] 1 [/SUP], Amanda M Casto[SUP] 1 2 [/SUP], Julia H Rogers[SUP] 1 3 [/SUP], Pavitra Roychoudhury[SUP] 2 4 [/SUP], Peter D Han[SUP] 5 6 [/SUP], Hong Xie[SUP] 4 [/SUP], Margaret G Mills[SUP] 4 [/SUP], Tien V Nguyen[SUP] 4 [/SUP], Brian Pfau[SUP] 5 6 [/SUP], Sarah N Cox[SUP] 1 3 [/SUP], Caitlin R Wolf[SUP] 1 [/SUP], James P Hughes[SUP] 2 7 [/SUP], Timothy M Uyeki[SUP] 8 [/SUP], Melissa A Rolfes[SUP] 8 [/SUP], Emily Mosites[SUP] 9 [/SUP], M Mia Shim[SUP] 10 11 [/SUP], Jeffrey S Duchin[SUP] 1 10 [/SUP], Nancy Sugg[SUP] 11 [/SUP], Lea A Starita[SUP] 2 4 [/SUP], Janet A Englund[SUP] 12 [/SUP], Helen Y Chu[SUP] 1 [/SUP]
Affiliations
- PMID: 35996440
- PMCID: PMC9387177
- DOI: 10.1016/j.lana.2022.100348
Abstract
Background: The circulation of respiratory viruses poses a significant health risk among those residing in congregate settings. Data are limited on seasonal human coronavirus (HCoV) infections in homeless shelter settings.
Methods: We analysed data from a clinical trial and SARS-CoV-2 surveillance study at 23 homeless shelter sites in King County, Washington between October 2019-May 2021. Eligible participants were shelter residents aged ≥3 months with acute respiratory illness. We collected enrolment data and nasal samples for respiratory virus testing using multiplex RT-PCR platform including HCoV. Beginning April 1, 2020, eligibility expanded to shelter residents and staff regardless of symptoms. HCoV species was determined by RT-PCR with species-specific primers, OpenArray assay or genomic sequencing for samples with an OpenArray relative cycle threshold <22.
Findings: Of the 14,464 samples from 3281 participants between October 2019-May 2021, 107 were positive for HCoV from 90 participants (median age 40 years, range: 0·9-81 years, 38% female). HCoV-HKU1 was the most common species identified before and after community-wide mitigation. No HCoV-positive samples were identified between May 2020-December 2020. Adults aged ≥50 years had the highest detection of HCoV (11%) among virus-positive samples among all age-groups. Species and sequence data showed diversity between and within HCoV species over the study period.
Interpretation: HCoV infections occurred in all congregate homeless shelter site age-groups with the greatest proportion among those aged ≥50 years. Species and sequencing data highlight the complexity of HCoV epidemiology within and between shelters sites.
Funding: Gates Ventures, Centers for Disease Control and Prevention, National Institute of Health.
Keywords: Homeless shelters; Homelessness; Human coronavirus; Respiratory viral infections.