tetano
Editor, Senior Moderator
Lancet Infect Dis
. 2020 Aug 17;S1473-3099(20)30651-4.
doi: 10.1016/S1473-3099(20)30651-4. Online ahead of print.
COVID-19 and multisystem inflammatory syndrome in children and adolescents
Li Jiang[SUP] 1 [/SUP], Kun Tang[SUP] 2 [/SUP], Mike Levin[SUP] 3 [/SUP], Omar Irfan[SUP] 1 [/SUP], Shaun K Morris[SUP] 4 [/SUP], Karen Wilson[SUP] 5 [/SUP], Jonathan D Klein[SUP] 6 [/SUP], Zulfiqar A Bhutta[SUP] 7 [/SUP]
Affiliations
Abstract
As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development. TRANSLATIONS: For the French, Chinese, Arabic, Spanish and Russian translations of the abstract see Supplementary Materials section.
. 2020 Aug 17;S1473-3099(20)30651-4.
doi: 10.1016/S1473-3099(20)30651-4. Online ahead of print.
COVID-19 and multisystem inflammatory syndrome in children and adolescents
Li Jiang[SUP] 1 [/SUP], Kun Tang[SUP] 2 [/SUP], Mike Levin[SUP] 3 [/SUP], Omar Irfan[SUP] 1 [/SUP], Shaun K Morris[SUP] 4 [/SUP], Karen Wilson[SUP] 5 [/SUP], Jonathan D Klein[SUP] 6 [/SUP], Zulfiqar A Bhutta[SUP] 7 [/SUP]
Affiliations
- PMID: 32818434
- DOI: 10.1016/S1473-3099(20)30651-4
Abstract
As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development. TRANSLATIONS: For the French, Chinese, Arabic, Spanish and Russian translations of the abstract see Supplementary Materials section.