tetano
Editor, Senior Moderator
J Infect Dis. 2013 Jul 11. [Epub ahead of print]
LAIV, but not PCV, protects against increased density and duration of pneumococcal carriage following influenza infection in pneumococcal colonized mice.
Mina MJ, Klugman KP, McCullers JA.
Source
Medical Scientist Training Program, Emory University School of Medicine.
Abstract
Secondary bacterial infections due to Streptococcus pneumoniae and Staphylococcus aureus, responsible for excess morbidity and mortality during influenza epidemics, are often preceded by excess bacterial density within the upper respiratory tract. Influenza and pneumococcal vaccines reduce secondary infections within the lungs, however their effects on upper respiratory tract carriage remain unknown. We demonstrate that a live attenuated influenza vaccine significantly reduces pneumococcal growth and duration of carriage during subsequent influenza to levels seen in influenza-na?ve controls. No benefit was seen following pneumococcal conjugate vaccine. Our results suggest that live attenuated influenza vaccines may significantly reduce bacterial disease during influenza epidemics.
PMID:
23852122
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23852122
LAIV, but not PCV, protects against increased density and duration of pneumococcal carriage following influenza infection in pneumococcal colonized mice.
Mina MJ, Klugman KP, McCullers JA.
Source
Medical Scientist Training Program, Emory University School of Medicine.
Abstract
Secondary bacterial infections due to Streptococcus pneumoniae and Staphylococcus aureus, responsible for excess morbidity and mortality during influenza epidemics, are often preceded by excess bacterial density within the upper respiratory tract. Influenza and pneumococcal vaccines reduce secondary infections within the lungs, however their effects on upper respiratory tract carriage remain unknown. We demonstrate that a live attenuated influenza vaccine significantly reduces pneumococcal growth and duration of carriage during subsequent influenza to levels seen in influenza-na?ve controls. No benefit was seen following pneumococcal conjugate vaccine. Our results suggest that live attenuated influenza vaccines may significantly reduce bacterial disease during influenza epidemics.
PMID:
23852122
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23852122