tetano
Editor, Senior Moderator
Lab Med
. 2022 Jun 28;lmac047.
doi: 10.1093/labmed/lmac047. Online ahead of print.
IgG-RBD Response Due to Inactivated SARS-CoV-2 Vaccine: Alteration in D-Dimer and Fibrinogen Concentrations, Association with Comorbidities and Adverse Effects
Murat Kaytaz[SUP] 1 [/SUP], Emre Akkaya[SUP] 1 [/SUP], Sefika Nur Gumus[SUP] 1 [/SUP], Sema Genc[SUP] 2 [/SUP], Halim Issever[SUP] 3 [/SUP], Beyhan Omer[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: To examine the immunoglobulin G-receptor-binding domain (IgG-RBD) response and changes in fibrinogen and D-dimer concentrations in individuals with a past coronavirus infection and followed by CoronaVac.
Methods: The study consisted of a total of 116 participants. Blood samples were drawn from subjects 21-25 days after they received first and second doses of CoronaVac as well as from individuals with a past infection. Fibrinogen, D-dimer, and IgG-RBD concentrations were measured.
Results: The IgG concentrations of the vaccinated subjects were significantly higher (P < .001), fibrinogen levels were lower (P < .001), and D-dimer levels increased following the second vaccination compared with the first vaccination (P = .083). No difference was obtained in IgG-RBD between vaccinated and previously infected individuals (P = .063). The differences in fibrinogen and D-dimer were statistically nonsignificant between both groups.
Conclusion: The CoronaVac vaccine appears to be safe and effective. It is essential for individuals to take personal protective measures, such as using masks and distancing.
Keywords: COVID-19 infection; D-dimer; fibrinogen; side effects; vaccination.
. 2022 Jun 28;lmac047.
doi: 10.1093/labmed/lmac047. Online ahead of print.
IgG-RBD Response Due to Inactivated SARS-CoV-2 Vaccine: Alteration in D-Dimer and Fibrinogen Concentrations, Association with Comorbidities and Adverse Effects
Murat Kaytaz[SUP] 1 [/SUP], Emre Akkaya[SUP] 1 [/SUP], Sefika Nur Gumus[SUP] 1 [/SUP], Sema Genc[SUP] 2 [/SUP], Halim Issever[SUP] 3 [/SUP], Beyhan Omer[SUP] 1 [/SUP]
Affiliations
- PMID: 35762784
- DOI: 10.1093/labmed/lmac047
Abstract
Objective: To examine the immunoglobulin G-receptor-binding domain (IgG-RBD) response and changes in fibrinogen and D-dimer concentrations in individuals with a past coronavirus infection and followed by CoronaVac.
Methods: The study consisted of a total of 116 participants. Blood samples were drawn from subjects 21-25 days after they received first and second doses of CoronaVac as well as from individuals with a past infection. Fibrinogen, D-dimer, and IgG-RBD concentrations were measured.
Results: The IgG concentrations of the vaccinated subjects were significantly higher (P < .001), fibrinogen levels were lower (P < .001), and D-dimer levels increased following the second vaccination compared with the first vaccination (P = .083). No difference was obtained in IgG-RBD between vaccinated and previously infected individuals (P = .063). The differences in fibrinogen and D-dimer were statistically nonsignificant between both groups.
Conclusion: The CoronaVac vaccine appears to be safe and effective. It is essential for individuals to take personal protective measures, such as using masks and distancing.
Keywords: COVID-19 infection; D-dimer; fibrinogen; side effects; vaccination.