tetano
Editor, Senior Moderator
Korean J Intern Med
. 2020 Sep 15.
doi: 10.3904/kjim.2020.325. Online ahead of print.
Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
Kyoung-Ho Song[SUP] 1 [/SUP], Dong-Min Kim[SUP] 2 [/SUP], Hyunju Lee[SUP] 3 [/SUP], Sin Young Ham[SUP] 1 [/SUP], Sang-Min Oh[SUP] 1 [/SUP], Hyeonju Jeong[SUP] 1 [/SUP], Jongtak Jung[SUP] 1 [/SUP], Chang Kyung Kang[SUP] 4 [/SUP], Ji Young Park[SUP] 3 [/SUP], Yu Min Kang[SUP] 5 [/SUP], Ji-Yeon Kim[SUP] 6 [/SUP], Jeong Su Park[SUP] 7 [/SUP], Kyoung Un Park[SUP] 7 [/SUP], Eu Suk Kim[SUP] 1 [/SUP], Hong Bin Kim[SUP] 1 [/SUP]
Affiliations
Abstract
The recent rise in the number of coronavirus disease 2019 (COVID-19) patients tested as reverse transcription polymerase chain reaction (RT-PCR) positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after recovery has caused dilemma regarding the medical measures and polices. We evaluated the dynamics of viral load and anti-SARS-CoV-2 antibodies in 4 patients with positive RT-PCR results after recovery. In all patients, IgG and IgM antibodies reached their maximum about a month after the onset of initial symptoms. Then, IgG titers plateaued, and IgM titers decreased regardless of RT-PCR results. The IgG and IgM antibodies did not rise after the positive-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to detection of RNA particles rather than re-infection or recurrence in individuals who have recovered from COVID-19.
Keywords: COVID-19; Reinfection; SARS-CoV-2.
. 2020 Sep 15.
doi: 10.3904/kjim.2020.325. Online ahead of print.
Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
Kyoung-Ho Song[SUP] 1 [/SUP], Dong-Min Kim[SUP] 2 [/SUP], Hyunju Lee[SUP] 3 [/SUP], Sin Young Ham[SUP] 1 [/SUP], Sang-Min Oh[SUP] 1 [/SUP], Hyeonju Jeong[SUP] 1 [/SUP], Jongtak Jung[SUP] 1 [/SUP], Chang Kyung Kang[SUP] 4 [/SUP], Ji Young Park[SUP] 3 [/SUP], Yu Min Kang[SUP] 5 [/SUP], Ji-Yeon Kim[SUP] 6 [/SUP], Jeong Su Park[SUP] 7 [/SUP], Kyoung Un Park[SUP] 7 [/SUP], Eu Suk Kim[SUP] 1 [/SUP], Hong Bin Kim[SUP] 1 [/SUP]
Affiliations
- PMID: 32972123
- DOI: 10.3904/kjim.2020.325
Abstract
The recent rise in the number of coronavirus disease 2019 (COVID-19) patients tested as reverse transcription polymerase chain reaction (RT-PCR) positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after recovery has caused dilemma regarding the medical measures and polices. We evaluated the dynamics of viral load and anti-SARS-CoV-2 antibodies in 4 patients with positive RT-PCR results after recovery. In all patients, IgG and IgM antibodies reached their maximum about a month after the onset of initial symptoms. Then, IgG titers plateaued, and IgM titers decreased regardless of RT-PCR results. The IgG and IgM antibodies did not rise after the positive-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to detection of RNA particles rather than re-infection or recurrence in individuals who have recovered from COVID-19.
Keywords: COVID-19; Reinfection; SARS-CoV-2.