tetano
Editor, Senior Moderator
Pediatr Int. 2017 Aug;59(8):929-931. doi: 10.1111/ped.13326.
[h=1]Kleine-Levin syndrome elicited by encephalopathy with reversible splenial lesion.[/h] Takayanagi M[SUP]1[/SUP], Okabe S[SUP]2[/SUP], Yamamoto K[SUP]3[/SUP], Komatsu J[SUP]1[/SUP], Suzuki R[SUP]1[/SUP], Kitamura T[SUP]1[/SUP], Ohura T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Kleine-Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13-year-old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5-10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine-Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine-Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.
? 2017 Japan Pediatric Society.
[h=4]KEYWORDS:[/h] clinically mild encephalitis/encephalopathy with a reversible splenial lesion; corpus callosum; influenza encephalopathy; periodic hypersomnolence; recurrent hypersomnia
PMID: 28804979 DOI: 10.1111/ped.13326
[h=1]Kleine-Levin syndrome elicited by encephalopathy with reversible splenial lesion.[/h] Takayanagi M[SUP]1[/SUP], Okabe S[SUP]2[/SUP], Yamamoto K[SUP]3[/SUP], Komatsu J[SUP]1[/SUP], Suzuki R[SUP]1[/SUP], Kitamura T[SUP]1[/SUP], Ohura T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Kleine-Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13-year-old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5-10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine-Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine-Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.
? 2017 Japan Pediatric Society.
[h=4]KEYWORDS:[/h] clinically mild encephalitis/encephalopathy with a reversible splenial lesion; corpus callosum; influenza encephalopathy; periodic hypersomnolence; recurrent hypersomnia
PMID: 28804979 DOI: 10.1111/ped.13326