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Klebsiella pneumoniae making inroads in Canada

Shiloh

Editor, Senior Moderator
Source: http://m.ctv.ca/topstories/20110918/superbug-outrebak-canada-klebsiella-pneumoniae-1109018.html

Sun Sep 18, 12:40 PM
Tricky new superbug making inroads in Canada
The Canadian Press

TORONTO ? A Montreal hospital has been battling for the last year to extinguish an outbreak with a worrisome and highly drug-resistant bacteria.

The outbreak at the Jewish General is the first in Canada caused by this strain of the bacteria, a bug that has sparked serious concern because of how easily it spreads and its ability to transfer resistance to other bacteria.

A report on the outbreak was presented in Chicago on Sunday to the Interscience Conference on Antimicrobial Agents and Chemotherapy, a major annual gathering of infectious diseases specialists.

Dr. Mark Miller, head of infection control at the Jewish General, said the outbreak has been brought under control, but a few patients with the bacteria are still being treated in the hospital.

The outbreak was caused by Klebsiella pneumoniae, which is normally found in the human intestine. In healthy people, these bacteria can live in the intestine without causing illness. In hospitals, however, they can cause a range of infections, including pneumonia, bloodstream infections and urinary tract infections.

Klebsiella pneumoniae traditionally have been treated with antibiotics called carbepenems. But in the last decade or so, a strain of the bacteria has developed that is resistant to this class of drugs. To make matters worse, the genetic component that gives Klebsiella pneumoniae this resistance has the capacity to transfer into other bacteria, making them resistant to these drugs as well...
 
Re: Klebsiella pneumoniae making inroads in Canada

A similar multiresistant Klebsiella (KPC) bacteria was found in Canada for the first time in 2008, Ottawa:

Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital Transmission

ABSTRACT
Klebsiella pneumoniae isolates from three patients admitted to the Ottawa Hospital, a 1,040-bed teaching hospital, were found to contain the plasmid-borne K. pneumoniae carbapenemase (KPC)-producing bla gene (blaKPC). There was evidence of person-to-person transmission for two patients. Screening of 186 clinical isolates revealed no additional blaKPC-containing isolates.

The first Klebsiella pneumoniae carbapenemase (KPC) was reported for an isolate collected from a North Carolina hospital through the Intensive Care Antimicrobial Resistance Epidemiology (ICARE) project (17).

Since then, KPC-producing isolates have been reported across the United States, especially in New York City, as well as among other Enterobacteriaceae (2, 3, 6, 9, 10).

These enzymes are particularly concerning because they confer resistance to all beta-lactam antibiotics and are carried on plasmids. We report the first three cases of KPC-producing K. pneumoniae in Canada and a retrospective surveillance for KPC-producing K. pneumoniae.

full article : J Clin Microbiol. 2009 June; 47(6): 1920?1922.
Published online 2009 April 8. doi: 10.1128/JCM.00098-09
 
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