tetano
Editor, Senior Moderator
Int J Clin Exp Med. 2014 Jul 15;7(7):1768-74. eCollection 2014.
Kinetic analysis of the immunity in a pregnant patient infected with avian influenza H7N9.
Qian W1, Jiang PC1, Qian J1, Jin ZC1, Yang J1, Lin J1, Wen XM1, Han FA2, Mao LX2, Yang J2, Deng ZQ1.
Author information
Abstract
BACKGROUND:
Human infection with avian influenza A H7N9 has emerged in China since February, 2013. The immunologic changes in pregnant women infected with H7N9 are not known.
OBJECTIVE:
To report the clinical data and kinetic changes of immunity in a pregnant woman infected with H7N9 virus in Zhenjiang, Jiangsu, China.
METHODS:
The clinical data were collected and immunity status was monitored in this patient.
RESULTS:
H7N9 virus became undetectable in sputum from 14 days since onset of symptoms after effective antiviral therapy with oseltamivir and symptomatic/supporting treatments. The symptoms and signs in this patient gradually improved from 15 days since onset of symptoms. Peripheral lymphocytes initially decreased and gradually increased. The percentage of CD4+ T cells increased since 16 days after onset of symptoms. The kinetic changes of cytokines including IFN-γ, IFN-α, TNF-α, IL-10 and TGF-β1 matched the development and recovery of illness. Her family members, including her parents exposed to H7N9 positive materials in poultry market, were H7N9 negative.
CONCLUSIONS:
Our results indicate that pregnant women are susceptible to H7N9 virus and H7N9 infection in pregnant women is curable without significant impact on fetus. Kinetic changes of pro-inflammatory and anti-inflammatory cytokines play a role in the pathogenesis and clinical outcome in the pregnant patient with H7N9 infection.
KEYWORDS:
H7N9; cytokine; pregnancy
PMID:
25126178
[PubMed]
PMCID:
PMC4132142
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25126178
Kinetic analysis of the immunity in a pregnant patient infected with avian influenza H7N9.
Qian W1, Jiang PC1, Qian J1, Jin ZC1, Yang J1, Lin J1, Wen XM1, Han FA2, Mao LX2, Yang J2, Deng ZQ1.
Author information
Abstract
BACKGROUND:
Human infection with avian influenza A H7N9 has emerged in China since February, 2013. The immunologic changes in pregnant women infected with H7N9 are not known.
OBJECTIVE:
To report the clinical data and kinetic changes of immunity in a pregnant woman infected with H7N9 virus in Zhenjiang, Jiangsu, China.
METHODS:
The clinical data were collected and immunity status was monitored in this patient.
RESULTS:
H7N9 virus became undetectable in sputum from 14 days since onset of symptoms after effective antiviral therapy with oseltamivir and symptomatic/supporting treatments. The symptoms and signs in this patient gradually improved from 15 days since onset of symptoms. Peripheral lymphocytes initially decreased and gradually increased. The percentage of CD4+ T cells increased since 16 days after onset of symptoms. The kinetic changes of cytokines including IFN-γ, IFN-α, TNF-α, IL-10 and TGF-β1 matched the development and recovery of illness. Her family members, including her parents exposed to H7N9 positive materials in poultry market, were H7N9 negative.
CONCLUSIONS:
Our results indicate that pregnant women are susceptible to H7N9 virus and H7N9 infection in pregnant women is curable without significant impact on fetus. Kinetic changes of pro-inflammatory and anti-inflammatory cytokines play a role in the pathogenesis and clinical outcome in the pregnant patient with H7N9 infection.
KEYWORDS:
H7N9; cytokine; pregnancy
PMID:
25126178
[PubMed]
PMCID:
PMC4132142
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25126178