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Kidney360 . Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis Patients

tetano

tetano

Editor, Senior Moderator
Kidney360


. 2022 Aug 9;3(10):1763-1768.
doi: 10.34067/KID.0002542022. eCollection 2022 Oct 27.
Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis Patients


Nicolas Valentini[SUP] 1 2 [/SUP], Lorie Marchitto[SUP] 3 4 [/SUP], Maxime Raymond[SUP] 1 [/SUP], Guillaume Goyette[SUP] 3 [/SUP], Daniel E Kaufmann[SUP] 3 5 [/SUP], Andrés Finzi[SUP] 3 4 [/SUP], Rita S Suri[SUP] 6 7 [/SUP], Caroline Lamarche[SUP] 1 5 [/SUP]



Affiliations

Abstract

Patients receiving hemodialysis (HD) have more inflammatory monocytes and less plasmacytoid dendritic cells (DCs) compared with healthy controls.Patients on HD who have a poor antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine had fewer monocyte-derived DCs and conventional DCs compared with good responders.The defects in antigen presentation might be possible therapeutic targets to increase vaccine efficacy in HD patients.

Keywords: COVID-19; SARS-CoV-2; basic science; chronic kidney disease; dendritic cell; immune response; innate immunity; mRNA vaccine; monocyte.
 
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