Kawaoka: hybridization of H1N1 and H5N1

[tetano]

Xinhua Tokyo on Aug. 5 (Xinhua blue construction), Japan Institute of Medicine, University of Tokyo professor Yoshihiro Kawaoka of the research team led by 5 in the United States "Virology" online edition published a thesis, H5N1 avian influenza virus are easy and Influenza H1N1 influenza virus hybrid features, although the H5N1 strain of bird flu virus does not easily infect humans, but with influenza H1N1 virus, after hybridization, there may be more contagious the birth of a new virus. Some experts think that influenza A H1N1 influenza virus from pigs, birds and human virus gene hybridization mixture formed in pigs. Study Group for H5N1 avian influenza virus and influenza A H1N1 influenza virus are also infected dog cells, and then analyzed the proliferation of the virus genes. It was found that the virus collected 59, 50 of the virus appeared genomic hybridization. Since then, the research team focuses on the influenza A H1N1 influenza virus play an important role on the proliferation of the PB1, PB2, PA, NP of four genes, these genes into H5N1 avian flu virus and replace the latter four genes, to produce 16 kinds of hybrid viruses. The results showed that the hybrid virus in infected human lung cells, have emerged proliferation, Erjuzengzhi skills become 更为 strong sense from the theory of characteristics means that the virus of infectious Zhe Zhong Zeng Qiang. On the other hand, if the H5N1 strain of bird flu virus, Influenza A H3N2 influenza virus combinations, for the same experiment will not produce the proliferation of hybrid or hybrid force after the virus is not strong. Yoshihiro Kawaoka of the view, indicating that, compared with influenza A H3N2 influenza virus, H1N1 avian flu virus and H5N1 virus gene easily cross. The participants were also pointed out that, due to influenza A H1N1 influenza virus itself may be formed in the hybrid pigs, so it and the H5N1 strain of bird flu virus in pigs may also cross into the proliferation of more new virus, to early detection of this possible of the new situation, the need to strengthen monitoring of pig vaccination.

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