JVI: Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H

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Published ahead of print 12 March 2014, doi: 10.1128/JVI.03319-13 JVI.03319-13

Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus.

Jiankang Han1,
Lili Wang2,
Jia Liu2,
Meihua Jin1,
Fangyuan Hao2,
Peng Zhang1,
Zhao Zhang2,
Dong Wen1,
Xiaofang Wu1,
Guangtao Liu1,
Lei Ji1,
Deshun Xu1,
Dongming Zhou2,
Qibin Leng2,
Ke Lan2# and
Chiyu Zhang2#

1 Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang, China
2 Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

ABSTRACT

We detected three avian influenza HA subtypes (H7, H9 and H5) and two NA subtypes (N9 and N2), as well as H7N9-related reassortant intermediates H9N9, co-circulating among poultry in Huzhou, China, during April 2013. The co-circulation not only reveals that Huzhou is one of the geographic origins of the novel H7N9 virus, but also poses a potential threat to humans in the future.

http://jvi.asm.org/content/early/2014/03/06/JVI.03319-13.abstract

 

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Re: JVI: Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus

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Chinese experts found that: One of Huzhou origin or H7N9

April 1, 2014 06:55:23 Hangzhou Network
　　
Pathogen Diagnostics Pasteur Institute of Chinese Academy of Sciences Shanghai R & D center in Huzhou City, Zhejiang Province Disease Prevention and Control Center to obtain new progress in the new H7N9 virus originated collaborative research, we found that one in Huzhou, Zhejiang origin or the new H7N9. Recently, research results, published online in the "Journal of Virology."
　　
Began in February 2013, China's Yangtze River Delta region by a new outbreak of a serious disease caused by H7N9 avian influenza virus. Huzhou City, Zhejiang Province, located in the north, is located in the hinterland of the Yangtze River Delta, Jiangsu, Anhui, bordering close to Shanghai, is one of the hardest hit by H7N9 epidemic. At the invitation of Huzhou City Center for Disease Control and Prevention, deputy director of Shanghai Pasteur led by researchers at Cold Blue Ke Kai Bin, ZHOU Dong-ming, Chang Chi-Yu and Wang Lili, Liu Jia and other technical staff of the research team, which went to collaborative research .
　　
By Huzhou April 2013 acquisition of poultry samples (manure, sewage, etc.) influenza gene fragments amplified, sequenced and phylogenetic analysis, the researchers found that the presence of poultry H7, H9, H5 HA three genotypes were popular and N9 and N2 NA genotypes of two popular; an evolutionary analysis of H9N2 influenza virus in six internal gene segments, there is always the outside tightly cluster formation in the evolution of the new H7N9 clusters, indicating (H9N2) is a genetically The most relevant and new H7N9 influenza virus strain H9N2. In addition, the study also found that two suspected H9N9 strains.
　　
The researchers said that north China's third largest freshwater lake in Huzhou Taihu Lake, has two natural wild habitat, with environmental conditions H7N9 origin, relevant research results suggest Huzhou is one of the origin of the new H7N9.

http://health.hangzhou.com.cn/new_4111249.html