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July Italy Sequences Released

Re: July Italy Sequences Released

LOCUS GQ422381 943 bp cRNA linear VRL 30-JUL-2009
DEFINITION Influenza A virus (A/Milan/83/2009(H1N1)) segment 4 hemagglutinin
(HA) gene, partial cds.
ACCESSION GQ422381
VERSION GQ422381.1 GI:254927648
DBLINK Project:37813
KEYWORDS .
SOURCE Influenza A virus (A/Milan/83/2009(H1N1))
ORGANISM Influenza A virus (A/Milan/83/2009(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 943)
AUTHORS Pariani,E., Canuti,M., Brambilla,D., Zanetti,A., Amendola,A.,
Tanzi,E., Frati,E., Colzani,D., Anselmi,G., Zappa,A. and Bianchi,S.
TITLE Swine influenza A (H1N1) virus isolated in Italy during human swine
flu outbreak of 2009
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 943)
AUTHORS Pariani,E., Canuti,M., Brambilla,D., Zanetti,A., Amendola,A.,
Tanzi,E., Frati,E., Colzani,D., Anselmi,G., Zappa,A. and Bianchi,S.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2009) Department of Public
Health-Microbiology-Virology, University of Milan, via C. Pascal
36, Milan 20133, Italy
COMMENT Swine influenza A (H1N1) virus isolated during human swine flu
outbreak of 2009.
FEATURES Location/Qualifiers
source 1..943
/organism="Influenza A virus (A/Milan/83/2009(H1N1))"
/mol_type="viral cRNA"
/strain="A/Milan/83/2009"
/serotype="H1N1"
/isolation_source="nasal swab"
/host="Homo sapiens"
/db_xref="taxon:663194"
/segment="4"
/country="Italy"
/collection_date="15-Jul-2009"
/note="lineage: swl"
gene <1..>943
/gene="HA"
CDS <1..>943
/gene="HA"
/codon_start=1
/product="hemagglutinin"
/protein_id="ACT85998.1"
/db_xref="GI:254927649"
/translation="VDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAG
WILGNPECESLSTASSWSYIVETSSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIF
PKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLV
LWGIHHPSTSADQQSLYQNANAYVFVGTSRYSKKFKPEIAIRPKVREQEGRMNYYWTL
VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLP
FQNIHSITIGKCPKYVKSTKLRLATGLRNVPSIQSRGL"
ORIGIN
1 gtagacacag tactagaaaa gaatgtaaca gtaacacact ctgttaacct tctagaagac
61 aagcataacg ggaaactatg caaactaaga ggggtagccc cattgcattt gggtaaatgt
121 aacattgctg gctggatcct gggaaatcca gagtgtgaat cactctccac agcaagctca
181 tggtcctaca ttgtggaaac atctagttca gacaatggaa cgtgttaccc aggagatttc
241 atcgattatg aggagctaag agagcaattg agctcagtgt catcatttga aaggtttgag
301 atattcccca agacaagttc atggcccaat catgactcga acaaaggtgt aacggcagca
361 tgtcctcatg ctggagcaaa aagcttctac aaaaatttaa tatggctagt taaaaaagga
421 aattcatacc caaagctcag caaatcctac attaatgata aagggaaaga agtcctcgtg
481 ctatggggca ttcaccatcc atctactagt gctgaccaac aaagtctcta tcagaatgca
541 aatgcatatg tttttgtggg gacatcaaga tacagcaaga agttcaagcc ggaaatagca
601 ataagaccca aagtgaggga acaagaaggg agaatgaact attactggac actagtagag
661 ccgggagaca aaataacatt cgaagcaact ggaaatctag tggtaccgag atatgcattc
721 gcaatggaaa gaaatgctgg atctggtatt atcatttcag atacaccagt ccacgattgc
781 aatacaactt gtcagacacc caagggtgct ataaacacca gcctcccatt tcagaatata
841 cattcgatca caattggaaa atgtccaaaa tatgtaaaaa gcacaaaatt gagactggcc
901 acaggattga ggaatgtccc gtctattcaa tctagaggcc tat
 
Re: July Italy Sequences Released

gb|GQ421203.1| Influenza A virus (A/Ancona/05/2009(H1N1)) seg... 38.2 0.19
gb|GQ387430.1| Influenza A virus (A/Catalonia/378/2009(H1N1))... 38.2 0.19
gb|GQ387382.1| Influenza A virus (A/Italy/172/2009(H1N1)) hem... 38.2 0.19
gb|GQ365446.1| Influenza A virus (A/Sapporo/1/2009(H1N1)) seg... 38.2 0.19
gb|GQ355305.1| Influenza A virus (A/Catalonia/387/2009(H1N1))... 38.2 0.19
gb|GQ351314.1| Influenza A virus (A/Hong Kong/2369/2009(H1N1)... 38.2 0.19
gb|GQ258700.1| Influenza A virus (A/Athens/893/2009(H1N1)) se... 38.2 0.19
gb|GQ249333.1| Influenza A virus (A/Paris/2591/2009(H1N1)) se... 38.2 0.19
gb|GQ160534.1| Influenza A virus (A/New Jersey/01/2009(H1N1))... 38.2 0.19
 
Re: July Italy Sequences Released

gb|GQ387430.1| Influenza A virus (A/Catalonia/378/2009(H1N1))... 40.1 0.047
gb|GQ387382.1| Influenza A virus (A/Italy/172/2009(H1N1)) hem... 40.1 0.047
gb|GQ351314.1| Influenza A virus (A/Hong Kong/2369/2009(H1N1)... 40.1 0.047
 
Re: July Italy Sequences Released

Jersey girl

Given how widespread the gene's from Jersey Girl's virus is, does that lend credibility to the notion that the New York area was the source of much of the global spread? There was a lot of anecdote of people returning from the New York area having gotten sick.
 
Re: July Italy Sequences Released

Given how widespread the gene's from Jersey Girl's virus is, does that lend credibility to the notion that the New York area was the source of much of the global spread? There was a lot of anecdote of people returning from the New York area having gotten sick.

Just looking at the 4 HA sequences from New Jersey, that New Jersey/01 has 3 different genes from the other. She hit the mutation jackpot.

.
 
Re: July Italy Sequences Released

But also comparing to the 169 sequences from New York, the Jersey/01 matches concensus in everyting except at 239 (my NCBI position) - she's the only one to have an "E" rather than the concensus "D". There are other minor variations in New York, but the Jersey girl is a conformist except for the one position. Why did that "E" make her such a winner?

.
 
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