tetano
Editor, Senior Moderator
Jpn J Infect Dis
. 2023 Apr 28.
doi: 10.7883/yoken.JJID.2022.677. Online ahead of print. A febrile reaction is associated with high IgG antibody titers after the second and third BNT162b2 vaccination in Japan
Nobuyasu Wakazono[SUP] 1 [/SUP], Katsura Nagai[SUP] 1 [/SUP], Arei Mizushima[SUP] 1 [/SUP], Yukiko Maeda[SUP] 1 [/SUP], Natsuko Taniguchi[SUP] 1 [/SUP], Toshiyuki Harada[SUP] 1 [/SUP], Emiko Satou[SUP] 2 [/SUP], Nao Mae[SUP] 2 [/SUP], Ken Furuya[SUP] 3 [/SUP]
Affiliations
Adverse events are potentially associated with an IgG response after the BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of BNT162b2 vaccination using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, just before the third vaccination, and 1 and 3 months after the third vaccination. A total of 505 participants who received three doses of vaccination were eligible for analysis. The results showed that post-vaccination body temperature correlated with anti-spike-receptor-binding domain (anti-S-RBD) antibody titers analyzed 3 months after the second (r = 0.30, p < 0.001) and third (r = 0.14, p < 0.001) vaccinations. Multivariate linear regression analysis revealed that age and severe swelling were negatively associated with log-transformed anti-S-RBD antibody levels, whereas sex (female), body temperature, and heat sensation were positively associated after the second vaccination. After the third vaccination, body temperature, and fatigue were positively associated with log-transformed anti-S-RBD antibody levels, and sex (female) was negatively associated. These results indicate that post-vaccination fever may be a marker of increased antibody titer.
Keywords: Adverse event; Anti-receptor-binding domain antibody; BNT162b2; Booster; SARS-CoV-2.
. 2023 Apr 28.
doi: 10.7883/yoken.JJID.2022.677. Online ahead of print. A febrile reaction is associated with high IgG antibody titers after the second and third BNT162b2 vaccination in Japan
Nobuyasu Wakazono[SUP] 1 [/SUP], Katsura Nagai[SUP] 1 [/SUP], Arei Mizushima[SUP] 1 [/SUP], Yukiko Maeda[SUP] 1 [/SUP], Natsuko Taniguchi[SUP] 1 [/SUP], Toshiyuki Harada[SUP] 1 [/SUP], Emiko Satou[SUP] 2 [/SUP], Nao Mae[SUP] 2 [/SUP], Ken Furuya[SUP] 3 [/SUP]
Affiliations
- PMID: 37121673
- DOI: 10.7883/yoken.JJID.2022.677
Adverse events are potentially associated with an IgG response after the BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of BNT162b2 vaccination using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, just before the third vaccination, and 1 and 3 months after the third vaccination. A total of 505 participants who received three doses of vaccination were eligible for analysis. The results showed that post-vaccination body temperature correlated with anti-spike-receptor-binding domain (anti-S-RBD) antibody titers analyzed 3 months after the second (r = 0.30, p < 0.001) and third (r = 0.14, p < 0.001) vaccinations. Multivariate linear regression analysis revealed that age and severe swelling were negatively associated with log-transformed anti-S-RBD antibody levels, whereas sex (female), body temperature, and heat sensation were positively associated after the second vaccination. After the third vaccination, body temperature, and fatigue were positively associated with log-transformed anti-S-RBD antibody levels, and sex (female) was negatively associated. These results indicate that post-vaccination fever may be a marker of increased antibody titer.
Keywords: Adverse event; Anti-receptor-binding domain antibody; BNT162b2; Booster; SARS-CoV-2.