tetano
Editor, Senior Moderator
Journal of Chemical Neuroanatomy
Available online 28 May 2013
In Press, Accepted Manuscript ? Note to users
Cover image
Comparative analyses of influenza virus receptor distribution in the human and mouse brains
Minsoo Kima,
Ji Eun Yua,
Jong-Hwan Leea,
Byung-Joon Changa,
Chang-Seon Songb,
Beobyi Leec,
Doo Jin Paikd,
Sang-Soep Nahma, Corresponding author contact information, E-mail the corresponding author
a Laboratory of Veterinary Anatomy, Konkuk University, Seoul 143-701, Korea
b Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
c Department of Anatomy, School of Medicine, Konkuk University, Seoul 143-701, Korea
d Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Korea
http://dx.doi.org/10.1016/j.jchemneu.2013.05.002
Highlights
?
Patterns of influenza receptor distribution in the mouse and human brains.
?
Comparison of the brain regions for influenza infection and receptor expression.
?
Influenza receptor expression in the brain endothelial cells and ependymal cells.
Abstract
Accumulating evidence suggests a potential link between influenza A virus infection and the occurrence of influenza-associated neurological disorders. As influenza infection is mediated by specific receptors on the host cell surface, it is important to understand the distribution patterns of influenza receptors in target organs. We carried out comprehensive experiments to localize influenza receptors in the brains of two different mouse strains and the human brain for comparison using lectin histochemistry. We further compared the brain regions in which influenza receptors were expressed and the regions in which experimental influenza infection was observed. Our results show that the expression patterns for influenza receptors in mouse and human brains are different. In the mouse brain, human influenza virus receptors (HuIV-R) were expressed in part of brainstem and cerebellar white matter while avian influenza virus receptors (AIV-R) were expressed in the cerebellar Purkinje neurons. In contrast, in the human brain, many neurons and glia in widespread regions, including the cerebral cortex, hippocampus, brainstem, and cerebellum, express both AIV-R and HuIV-R. Importantly, vascular endothelial cells, choroid plexus epithelial cells and ependymal cells in both mouse and human brains express high levels of HuIV-R and AIV-R. The regional reciprocity was not observed when comparing regions with influenza receptor expression and the regions of influenza infection within the mouse brain. Our results demonstrate a differential influenza receptor expression pattern in mouse and human brains, and a disparity between influenza receptor distribution and regions with actual influenza infection.
http://www.sciencedirect.com/science/article/pii/S0891061813000562
Available online 28 May 2013
In Press, Accepted Manuscript ? Note to users
Cover image
Comparative analyses of influenza virus receptor distribution in the human and mouse brains
Minsoo Kima,
Ji Eun Yua,
Jong-Hwan Leea,
Byung-Joon Changa,
Chang-Seon Songb,
Beobyi Leec,
Doo Jin Paikd,
Sang-Soep Nahma, Corresponding author contact information, E-mail the corresponding author
a Laboratory of Veterinary Anatomy, Konkuk University, Seoul 143-701, Korea
b Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
c Department of Anatomy, School of Medicine, Konkuk University, Seoul 143-701, Korea
d Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Korea
http://dx.doi.org/10.1016/j.jchemneu.2013.05.002
Highlights
?
Patterns of influenza receptor distribution in the mouse and human brains.
?
Comparison of the brain regions for influenza infection and receptor expression.
?
Influenza receptor expression in the brain endothelial cells and ependymal cells.
Abstract
Accumulating evidence suggests a potential link between influenza A virus infection and the occurrence of influenza-associated neurological disorders. As influenza infection is mediated by specific receptors on the host cell surface, it is important to understand the distribution patterns of influenza receptors in target organs. We carried out comprehensive experiments to localize influenza receptors in the brains of two different mouse strains and the human brain for comparison using lectin histochemistry. We further compared the brain regions in which influenza receptors were expressed and the regions in which experimental influenza infection was observed. Our results show that the expression patterns for influenza receptors in mouse and human brains are different. In the mouse brain, human influenza virus receptors (HuIV-R) were expressed in part of brainstem and cerebellar white matter while avian influenza virus receptors (AIV-R) were expressed in the cerebellar Purkinje neurons. In contrast, in the human brain, many neurons and glia in widespread regions, including the cerebral cortex, hippocampus, brainstem, and cerebellum, express both AIV-R and HuIV-R. Importantly, vascular endothelial cells, choroid plexus epithelial cells and ependymal cells in both mouse and human brains express high levels of HuIV-R and AIV-R. The regional reciprocity was not observed when comparing regions with influenza receptor expression and the regions of influenza infection within the mouse brain. Our results demonstrate a differential influenza receptor expression pattern in mouse and human brains, and a disparity between influenza receptor distribution and regions with actual influenza infection.
http://www.sciencedirect.com/science/article/pii/S0891061813000562