sharon sanders
Editor-in-Chief & President
[h=1]High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children[/h]
-Author Affiliations
[h=2]Abstract[/h] Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are also antibodies which bind to influenza virus-infected cells and mediate lysis of the infected cells by NK cells (antibody-dependent cellular cytotoxicity or ADCC) or complement (complement-dependent lysis, or CDL). We analyzed sera obtained from 16 healthy adults (18-63 years of age), 52 children (2-17 years of age) and 10 infants (0.75-1 year of age) in the U.S., who are unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but unexpectedly we found the presence of high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children over 8 years old.
http://jid.oxfordjournals.org/content/early/2015/03/20/infdis.jiv181.short?rss=1
-Author Affiliations
- Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, 01655, U.S.A
- Corresponding Author: Masanori Terajima, FAX: 1-508-586-4890, Telephone: 1-508-856-2886, e-mail: Masanori.Terajima@umassmed.edu
- ↵* These authors contributed equally to this work.
[h=2]Abstract[/h] Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are also antibodies which bind to influenza virus-infected cells and mediate lysis of the infected cells by NK cells (antibody-dependent cellular cytotoxicity or ADCC) or complement (complement-dependent lysis, or CDL). We analyzed sera obtained from 16 healthy adults (18-63 years of age), 52 children (2-17 years of age) and 10 infants (0.75-1 year of age) in the U.S., who are unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but unexpectedly we found the presence of high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children over 8 years old.
http://jid.oxfordjournals.org/content/early/2015/03/20/infdis.jiv181.short?rss=1