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Joint United Kingdom (UK) Monkeypox: Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

M

Mary Wilson

Well-known member
https://www.transfusionguidelines.org/dsg/wb/guidelines/monkeypox

[TD="colspan: 2"]
ObligatoryMust not donate
DiscretionaryIf the donor has recovered from confirmed or suspected Monkeypox (MPX) infection and
  • It is at least 28 days since the diagnosis of MPX was made, and
  • It is at least 14 days since recovery and the donor remains well, and
  • It is at least 14 days since all skin lesions have healed, and
  • It is more than seven days since completing any antiviral or antibiotic therapy, and
  • The donor has been discharged from all follow up (including public health surveillance)
accept
Additional InformationMPX is endemic in some African countries. During 2022 a multi-country outbreak was identified with cases in the UK, Europe, North America and other regions.



The incubation period of MPX is up to 21 days. The initial symptom are fever, myalgia, fatigue and headache. These symptoms are followed by a rash starting from the site of the primary infection, this rash develops into vesicles and pustule followed by scabs. Infectivity may start during initial symptoms and lasts until the rash clears and all scabs have dropped off.



Staff should be alert for donors who report rashes and illnesses consistent with monkeypox, regardless of sexual behaviour, travel history or other risk factors.

[TD="colspan: 2"]1. Affected Individuals[/TD]
[/TD]

[TD="colspan: 2"]
IncludesIndividuals who have been identified by public health teams as a close contact of an individual with Monkeypox
ObligatoryMust not donate
DiscretionaryIf it is more than 21 days since last contact and,
  • the donor has no symptoms of monkeypox and
  • the donor has completed any isolation period, and
  • the donor has been discharged from all follow-up (including surveillance by public health),
accept.

See additional information below for donors who received vaccination.

Additional InformationMPX does not spread easily between people. Human-to-human transmission occurs through contact with:
  • infectious material from skin lesions
  • respiratory droplets in prolonged face-to-face contact
  • virus-contaminated objects such as bedding or clothing


During the 2022 multi-country outbreak, the predominance of cases among men who have sex with men and the distribution of the MPX skin rash at presentation, suggests MPX transmission is associated with direct contact during sex.



Contacts may have received Imvanex, a third generation Smallpox vaccination, to reduce the risk of serious illness. Imvanex is a live attenuated non-replicating vaccination. For donor selection purposes this should be assessed as a non-live vaccine. Recipients of Imvanex are eligible to donate once they satisfy the requirements of the discretionary entry above.

[TD="colspan: 2"]2. Contact with an individual with Monkeypox[/TD]
[/TD]
 
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