tetano
Editor, Senior Moderator
JNCI Cancer Spectr
. 2021 Jan 6;5(1)
kaa090.
doi: 10.1093/jncics/pkaa090. eCollection 2021 Feb.
Characteristics and Outcome of SARS-CoV-2 Infection in Cancer Patients
Cl?mence Basse[SUP] 1 [/SUP], Sarah Diakite[SUP] 1 [/SUP], Vincent Servois[SUP] 2 [/SUP], Maxime Frelaut[SUP] 3 [/SUP], Aur?lien Noret[SUP] 1 [/SUP], Audrey Bellesoeur[SUP] 1 [/SUP], Pauline Moreau[SUP] 1 [/SUP], Marie-Ange Massiani[SUP] 1 [/SUP], Anne-Sophie Bouyer[SUP] 1 [/SUP], Perrine Vuagnat[SUP] 1 4 [/SUP], Sandra Malak[SUP] 1 [/SUP], Fran?ois-Cl?ment Bidard[SUP] 1 4 [/SUP], Dominique Vanjak[SUP] 5 [/SUP], Ir?ne Kriegel[SUP] 6 [/SUP], Alexis Burnod[SUP] 7 [/SUP], Geoffroy Bilger[SUP] 1 [/SUP], Toulsie Ramtohul[SUP] 2 [/SUP], Gilles Dhonneur[SUP] 6 [/SUP], Carole Bouleuc[SUP] 7 [/SUP], Nathalie Cassoux[SUP] 8 9 [/SUP], Institut Curie COVID Group,; Xavier Paoletti[SUP] 1 4 [/SUP], Laurence Bozec[SUP] 1 [/SUP], Paul Cottu[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Concerns have emerged about the higher risk of fatal coronavirus disease 2019 (COVID-19) in cancer patients. In this article, we review the experience of a comprehensive cancer center.
Methods: A prospective registry was set up at Institut Curie at the beginning of the COVID-19 pandemic. All cancer patients with suspected or proven COVID-19 were entered and actively followed for 28 days.
Results: Among 9842 patients treated at Institut Curie between March 13 and May 1, 2020, 141 (1.4%) were diagnosed with COVID-19, based on reverse transcription polymerase chain reaction testing and/or computerized tomography scan. In line with our case mix, breast cancer (40.4%) was the most common tumor type, followed by hematological and lung malignancies. Patients with active cancer therapy or/and advanced cancer accounted for 87.9% and 68.9% of patients, respectively. At diagnosis, 78.7% of patients had COVID-19-related symptoms, with an extent of lung parenchyma involvement inferior to 50% in 95.8% of patients. Blood count variations and C-reactive protein elevation were the most common laboratory abnormalities. Antibiotics and antiviral agents were administered in 48.2% and 6.4% of patients, respectively. At the time of analysis, 26 patients (18.4%) have died from COVID-19, and 100 (70.9%) were cured. Independent prognostic factors at the time of COVID-19 diagnosis associated with death or intensive care unit admission were extent of COVID-19 pneumonia and decreased O[SUB]2[/SUB] saturation.
Conclusions: COVID-19 incidence and presentation in cancer patients appear to be very similar to those in the general population. The outcome of COVID-19 is primarily driven by the initial severity of infection rather than patient or cancer characteristics.
. 2021 Jan 6;5(1)
kaa090.doi: 10.1093/jncics/pkaa090. eCollection 2021 Feb.
Characteristics and Outcome of SARS-CoV-2 Infection in Cancer Patients
Cl?mence Basse[SUP] 1 [/SUP], Sarah Diakite[SUP] 1 [/SUP], Vincent Servois[SUP] 2 [/SUP], Maxime Frelaut[SUP] 3 [/SUP], Aur?lien Noret[SUP] 1 [/SUP], Audrey Bellesoeur[SUP] 1 [/SUP], Pauline Moreau[SUP] 1 [/SUP], Marie-Ange Massiani[SUP] 1 [/SUP], Anne-Sophie Bouyer[SUP] 1 [/SUP], Perrine Vuagnat[SUP] 1 4 [/SUP], Sandra Malak[SUP] 1 [/SUP], Fran?ois-Cl?ment Bidard[SUP] 1 4 [/SUP], Dominique Vanjak[SUP] 5 [/SUP], Ir?ne Kriegel[SUP] 6 [/SUP], Alexis Burnod[SUP] 7 [/SUP], Geoffroy Bilger[SUP] 1 [/SUP], Toulsie Ramtohul[SUP] 2 [/SUP], Gilles Dhonneur[SUP] 6 [/SUP], Carole Bouleuc[SUP] 7 [/SUP], Nathalie Cassoux[SUP] 8 9 [/SUP], Institut Curie COVID Group,; Xavier Paoletti[SUP] 1 4 [/SUP], Laurence Bozec[SUP] 1 [/SUP], Paul Cottu[SUP] 1 [/SUP]
Affiliations
- PMID: 33604509
- PMCID: PMC7665636
- DOI: 10.1093/jncics/pkaa090
Abstract
Background: Concerns have emerged about the higher risk of fatal coronavirus disease 2019 (COVID-19) in cancer patients. In this article, we review the experience of a comprehensive cancer center.
Methods: A prospective registry was set up at Institut Curie at the beginning of the COVID-19 pandemic. All cancer patients with suspected or proven COVID-19 were entered and actively followed for 28 days.
Results: Among 9842 patients treated at Institut Curie between March 13 and May 1, 2020, 141 (1.4%) were diagnosed with COVID-19, based on reverse transcription polymerase chain reaction testing and/or computerized tomography scan. In line with our case mix, breast cancer (40.4%) was the most common tumor type, followed by hematological and lung malignancies. Patients with active cancer therapy or/and advanced cancer accounted for 87.9% and 68.9% of patients, respectively. At diagnosis, 78.7% of patients had COVID-19-related symptoms, with an extent of lung parenchyma involvement inferior to 50% in 95.8% of patients. Blood count variations and C-reactive protein elevation were the most common laboratory abnormalities. Antibiotics and antiviral agents were administered in 48.2% and 6.4% of patients, respectively. At the time of analysis, 26 patients (18.4%) have died from COVID-19, and 100 (70.9%) were cured. Independent prognostic factors at the time of COVID-19 diagnosis associated with death or intensive care unit admission were extent of COVID-19 pneumonia and decreased O[SUB]2[/SUB] saturation.
Conclusions: COVID-19 incidence and presentation in cancer patients appear to be very similar to those in the general population. The outcome of COVID-19 is primarily driven by the initial severity of infection rather than patient or cancer characteristics.