tetano
Editor, Senior Moderator
JACC Case Rep
. 2020 Oct 28.
doi: 10.1016/j.jaccas.2020.08.025. Online ahead of print.
Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review
James C Gubitosa[SUP] 1 [/SUP], Parul Kakar[SUP] 2 [/SUP], Christine Gerula[SUP] 2 [/SUP], Hernando Nossa[SUP] 3 [/SUP], Diana Finkel[SUP] 3 [/SUP], Kristin Wong[SUP] 4 [/SUP], Megna Khatri[SUP] 4 [/SUP], Hasan Ali[SUP] 1 [/SUP]
Affiliations
Abstract
Remdesivir has seen extensive use during the coronavirus disease-2019 pandemic given its clinically proven efficacy against severe acute respiratory syndrome coronavirus type 2. There has been little cited regarding adverse effects. Here we present the case of a patient with marked sinus bradycardia that began acutely on initiation of remdesivir and resolved almost immediately on cessation of the drug. (Level of Difficulty: Beginner.).
Keywords: AV, atrioventricular; COVID-19, coronavirus disease-2019; ECG, electrocardiogram; LBBB, left bundle branch block; bradycardia; cancer; cardiovascular disease; chest pain; electrocardiogram; electrophysiology; h-mtRNAP, human mitochondrial RNA polymerase; lethargy; physical examination; shortness of breath.
. 2020 Oct 28.
doi: 10.1016/j.jaccas.2020.08.025. Online ahead of print.
Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review
James C Gubitosa[SUP] 1 [/SUP], Parul Kakar[SUP] 2 [/SUP], Christine Gerula[SUP] 2 [/SUP], Hernando Nossa[SUP] 3 [/SUP], Diana Finkel[SUP] 3 [/SUP], Kristin Wong[SUP] 4 [/SUP], Megna Khatri[SUP] 4 [/SUP], Hasan Ali[SUP] 1 [/SUP]
Affiliations
- PMID: 33163977
- PMCID: PMC7598346
- DOI: 10.1016/j.jaccas.2020.08.025
Abstract
Remdesivir has seen extensive use during the coronavirus disease-2019 pandemic given its clinically proven efficacy against severe acute respiratory syndrome coronavirus type 2. There has been little cited regarding adverse effects. Here we present the case of a patient with marked sinus bradycardia that began acutely on initiation of remdesivir and resolved almost immediately on cessation of the drug. (Level of Difficulty: Beginner.).
Keywords: AV, atrioventricular; COVID-19, coronavirus disease-2019; ECG, electrocardiogram; LBBB, left bundle branch block; bradycardia; cancer; cardiovascular disease; chest pain; electrocardiogram; electrophysiology; h-mtRNAP, human mitochondrial RNA polymerase; lethargy; physical examination; shortness of breath.