tetano
Editor, Senior Moderator
JACC Basic Transl Sci
. 2022 Feb 9.
doi: 10.1016/j.jacbts.2021.10.011. Online ahead of print.
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review
Bhurint Siripanthong[SUP] 1 [/SUP], Babken Asatryan[SUP] 2 [/SUP], Thomas C Hanff[SUP] 3 [/SUP], Salman R Chatha[SUP] 4 5 [/SUP], Mohammed Y Khanji[SUP] 4 6 7 [/SUP], Fabrizio Ricci[SUP] 8 9 10 [/SUP], Daniele Muser[SUP] 11 [/SUP], Victor A Ferrari[SUP] 12 13 [/SUP], Saman Nazarian[SUP] 14 [/SUP], Pasquale Santangeli[SUP] 14 [/SUP], Rajat Deo[SUP] 14 [/SUP], Leslie T Cooper Jr[SUP] 15 [/SUP], Saidi A Mohiddin[SUP] 4 7 [/SUP], C Anwar A Chahal[SUP] 4 14 16 17 [/SUP]
Affiliations
Abstract
The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
Keywords: CMR, cardiovascular magnetic resonance; COVID-19; COVID-19, coronavirus disease 2019; CT, Computerized Tomography; LGE, late gadolinium enhancement; MI, myocardial infarction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; athlete; cardiovascular magnetic resonance imaging; inflammation; myocardial injury; myocarditis; sudden cardiac death; troponin.
. 2022 Feb 9.
doi: 10.1016/j.jacbts.2021.10.011. Online ahead of print.
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review
Bhurint Siripanthong[SUP] 1 [/SUP], Babken Asatryan[SUP] 2 [/SUP], Thomas C Hanff[SUP] 3 [/SUP], Salman R Chatha[SUP] 4 5 [/SUP], Mohammed Y Khanji[SUP] 4 6 7 [/SUP], Fabrizio Ricci[SUP] 8 9 10 [/SUP], Daniele Muser[SUP] 11 [/SUP], Victor A Ferrari[SUP] 12 13 [/SUP], Saman Nazarian[SUP] 14 [/SUP], Pasquale Santangeli[SUP] 14 [/SUP], Rajat Deo[SUP] 14 [/SUP], Leslie T Cooper Jr[SUP] 15 [/SUP], Saidi A Mohiddin[SUP] 4 7 [/SUP], C Anwar A Chahal[SUP] 4 14 16 17 [/SUP]
Affiliations
- PMID: 35165665
- PMCID: PMC8828362
- DOI: 10.1016/j.jacbts.2021.10.011
Abstract
The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
Keywords: CMR, cardiovascular magnetic resonance; COVID-19; COVID-19, coronavirus disease 2019; CT, Computerized Tomography; LGE, late gadolinium enhancement; MI, myocardial infarction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; athlete; cardiovascular magnetic resonance imaging; inflammation; myocardial injury; myocarditis; sudden cardiac death; troponin.