tetano
Editor, Senior Moderator
JAAD Int
. 2021 Dec 28.
doi: 10.1016/j.jdin.2021.12.007. Online ahead of print.
The Association between Atopic Dermatitis and COVID-19 infection: A Case-Control Study in the All of Us Research Program
Ryan Fan[SUP] 1 [/SUP], Audrey C Leasure[SUP] 1 [/SUP], William Damsky[SUP] 2 3 [/SUP], Jeffrey M Cohen[SUP] 2 [/SUP]
Affiliations
Abstract
Background: There is incomplete understanding of the risk of coronavirus disease 2019 (COVID-19) infection in atopic dermatitis (AD) patients.
Objective: To evaluate the risk of COVID-19 infection in AD patients in a large, diverse cohort.
Methods: A case-control study of the All of Us cohort to analyze the association between AD and COVID-19. Comorbidities and risk factors were compared between cases and controls using multivariable analyses.
Results: In a cohort of 11,752 AD cases with 47,008 matched controls, AD patients were more likely to have a COVID-19 diagnosis (4.2% vs. 2.8%, P <0.001) compared to controls. AD remained significantly associated with COVID-19 in multivariable analysis (OR 1.29, P<0.001) after adjusting for demographic factors and comorbidities.
Limitations: Ascertainment of AD and COVID-19 cases using electronic health records and lack of clinical data on AD severity or therapy and COVID-19 outcomes.
Conclusions: AD is associated with increased odds of COVID-19 infection even after controlling for common comorbidities.
Keywords: COVID-19; atopic dermatitis; epidemiology.
. 2021 Dec 28.
doi: 10.1016/j.jdin.2021.12.007. Online ahead of print.
The Association between Atopic Dermatitis and COVID-19 infection: A Case-Control Study in the All of Us Research Program
Ryan Fan[SUP] 1 [/SUP], Audrey C Leasure[SUP] 1 [/SUP], William Damsky[SUP] 2 3 [/SUP], Jeffrey M Cohen[SUP] 2 [/SUP]
Affiliations
- PMID: 34977817
- PMCID: PMC8712258
- DOI: 10.1016/j.jdin.2021.12.007
Abstract
Background: There is incomplete understanding of the risk of coronavirus disease 2019 (COVID-19) infection in atopic dermatitis (AD) patients.
Objective: To evaluate the risk of COVID-19 infection in AD patients in a large, diverse cohort.
Methods: A case-control study of the All of Us cohort to analyze the association between AD and COVID-19. Comorbidities and risk factors were compared between cases and controls using multivariable analyses.
Results: In a cohort of 11,752 AD cases with 47,008 matched controls, AD patients were more likely to have a COVID-19 diagnosis (4.2% vs. 2.8%, P <0.001) compared to controls. AD remained significantly associated with COVID-19 in multivariable analysis (OR 1.29, P<0.001) after adjusting for demographic factors and comorbidities.
Limitations: Ascertainment of AD and COVID-19 cases using electronic health records and lack of clinical data on AD severity or therapy and COVID-19 outcomes.
Conclusions: AD is associated with increased odds of COVID-19 infection even after controlling for common comorbidities.
Keywords: COVID-19; atopic dermatitis; epidemiology.