Giuseppe
Emeritus
Unseasonal Transmission of H3N2 Influenza A Virus During the Swine-Origin H1N1 Pandemic. (J Virol., abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 17. [Epub ahead of print]
Unseasonal Transmission of H3N2 Influenza A Virus During the Swine-Origin H1N1 Pandemic.
Ghedin E, Wentworth D, Halpin RA, Lin X, Bera J, Depasse J, Fitch A, Griesemer S, Hine E, Katzel DA, Overton L, Proudfoot K, Sitz J, Szczypinski B, St George K, Spiro DJ, Holmes EC. - Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Wadsworth Center, NYSDH, Albany, New York, 12201, USA; School of Public Health, State University of New York, Albany, New York 12201, USA; J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA; Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
The initial wave of swine-origin influenza A virus (pandemic H1N1/09) in the United States during the spring-summer of 2009 also resulted in an increased vigilance and sampling of seasonal influenza viruses (H1N1 and H3N2), even though they are normally characterized by very low incidence outside of the winter months. To explore the nature of virus evolution during this influenza 'off-season' we conducted a phylogenetic analysis of H1N1 and H3N2 sequences sampled during April-June 2009 in New York State, USA. Our analysis revealed that multiple lineages of both viruses were introduced and co-circulated during this time, as is typical of influenza virus during the winter. Strikingly, however, we also found strong evidence for the presence of a large transmission chain of H3N2 viruses centered on the south-east of New York State and which continued until at least June 1(st) 2009. These results suggest that the unseasonal transmission of influenza A viruses may be more widespread than is usually supposed.
PMID: 20237080 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 17. [Epub ahead of print]
Unseasonal Transmission of H3N2 Influenza A Virus During the Swine-Origin H1N1 Pandemic.
Ghedin E, Wentworth D, Halpin RA, Lin X, Bera J, Depasse J, Fitch A, Griesemer S, Hine E, Katzel DA, Overton L, Proudfoot K, Sitz J, Szczypinski B, St George K, Spiro DJ, Holmes EC. - Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Wadsworth Center, NYSDH, Albany, New York, 12201, USA; School of Public Health, State University of New York, Albany, New York 12201, USA; J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA; Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
The initial wave of swine-origin influenza A virus (pandemic H1N1/09) in the United States during the spring-summer of 2009 also resulted in an increased vigilance and sampling of seasonal influenza viruses (H1N1 and H3N2), even though they are normally characterized by very low incidence outside of the winter months. To explore the nature of virus evolution during this influenza 'off-season' we conducted a phylogenetic analysis of H1N1 and H3N2 sequences sampled during April-June 2009 in New York State, USA. Our analysis revealed that multiple lineages of both viruses were introduced and co-circulated during this time, as is typical of influenza virus during the winter. Strikingly, however, we also found strong evidence for the presence of a large transmission chain of H3N2 viruses centered on the south-east of New York State and which continued until at least June 1(st) 2009. These results suggest that the unseasonal transmission of influenza A viruses may be more widespread than is usually supposed.
PMID: 20237080 [PubMed - as supplied by publisher]
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