Giuseppe
Emeritus
Systemic Dissemination of H5N1 Influenza A Viruses in Ferrets and Hamsters After Direct Intragastric Inoculation. (Abstract, edited)
[Source: US National Library of Medicine, full text (LINK). Abstract, edited.]
J Virol. 2011 Mar 16. [Epub ahead of print]
Systemic Dissemination of H5N1 Influenza A Viruses in Ferrets and Hamsters After Direct Intragastric Inoculation.
Shinya K, Makino A, Tanaka H, Hatta M, Watanabe T, Le MQ, Imai H, Kawaoka Y. - raduate School of Medicine, Kobe University 650-0017, Japan; Tanaka Animal Hospital, Tottori 680-0062, Japan; Department of Pathobiological Sciences, University of Wisconsin- Madison, Madison, Wisconsin 53706, USA; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan.
Although oral exposure to H5N1 highly pathogenic avian influenza viruses is a risk factor for infection in humans, it is unclear how oral exposure to these virus results in lethal respiratory infections. To address this issue, we inoculated ferrets and hamsters with two highly pathogenic H5N1 strains. These viruses, inoculated directly into the stomach, were isolated from the large intestine and the mesenteric lymph nodes within one day of inoculation, and subsequently spread to multiple tissues, including lung, liver, and brain. Histopathologic analysis of ferrets infected with virus via direct intragastric inoculation revealed lymph folliculitis in the digestive tract and mesenteric lymph nodes, and focal interstitial pneumonia. Comparable results were obtained with the hamster model. We conclude that, in mammals, ingested H5N1 influenza viruses can disseminate to non-digestive organs, possibly through the lymphatic system of the gastrointestinal tract.
PMID: 21411541 [PubMed - as supplied by publisher]
-
------
[Source: US National Library of Medicine, full text (LINK). Abstract, edited.]
J Virol. 2011 Mar 16. [Epub ahead of print]
Systemic Dissemination of H5N1 Influenza A Viruses in Ferrets and Hamsters After Direct Intragastric Inoculation.
Shinya K, Makino A, Tanaka H, Hatta M, Watanabe T, Le MQ, Imai H, Kawaoka Y. - raduate School of Medicine, Kobe University 650-0017, Japan; Tanaka Animal Hospital, Tottori 680-0062, Japan; Department of Pathobiological Sciences, University of Wisconsin- Madison, Madison, Wisconsin 53706, USA; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan.
Although oral exposure to H5N1 highly pathogenic avian influenza viruses is a risk factor for infection in humans, it is unclear how oral exposure to these virus results in lethal respiratory infections. To address this issue, we inoculated ferrets and hamsters with two highly pathogenic H5N1 strains. These viruses, inoculated directly into the stomach, were isolated from the large intestine and the mesenteric lymph nodes within one day of inoculation, and subsequently spread to multiple tissues, including lung, liver, and brain. Histopathologic analysis of ferrets infected with virus via direct intragastric inoculation revealed lymph folliculitis in the digestive tract and mesenteric lymph nodes, and focal interstitial pneumonia. Comparable results were obtained with the hamster model. We conclude that, in mammals, ingested H5N1 influenza viruses can disseminate to non-digestive organs, possibly through the lymphatic system of the gastrointestinal tract.
PMID: 21411541 [PubMed - as supplied by publisher]
-
------