Giuseppe
Emeritus
Killing of avian and swine influenza by Natural Killer cells. (J Virol., abstract, edited)
8. J Virol. 2010 Feb 3. [Epub ahead of print]
Killing of avian and swine influenza by Natural Killer cells.
Achdout H, Segman T, Hirsh S, Glasner A, Bar-On Y, Gur C, Porgador A, Mendelson M, Mandelboim M, Mandelboim O. - The Lautenberg Center for general and Tumor Immunology, IMRIC, the Hebrew University Hadassah Medical School, Jerusalem, Israel; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel; Central Virology Laboratory, Ministry of Health, Public health Services, Chaim, Sheba medical Center, Tel Hashomer, Ramat-Gan Israel; Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and Cancer Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Today, a global attention is focused on two influenza virus strains, the current pandemic strain, swine-origin influenza virus (H1N1-2009) and the highly pathogenic avian influenza, H5N1. As for now, the infection caused by the H1N1-2009 is moderate with mortality rates of less than 1%. In contrast, infection with the H5N1 virus resulted in high mortality rates and around 60% of the infected patients succumb to the infection. Thus, one of the world greatest concerns is that the H5N1 virus will evolve to allow an efficient human infection and human-to-human transmission. Natural killer (NK) cells are one of the innate immune components playing an important role in fighting against influenza viruses. One of the major NK activating receptors involved in NK cell cytotoxicity is NKp46. We previously demonstrated that NKp46 recognizes the hemagglutinin proteins of B and A influenza virus strains. Whereas NKp46 could also interact with H1N1-2009 virus or with the avian influenza virus is still unknown. Here we analyzed the immunological properties of both the avian and the H1N1-2009 influenza viruses. We show that NKp46 recognizes the hemagglutinins of H1N1-2009 and H5 and that this recognition leads to virus killing both in vitro and in vivo. However, importantly, while the swine H1-NKp46 interactions lead to the direct killing of the infected cells, the H5-NKp46 interactions were unable to elicit direct killing, probably because the NKp46 binding sites for these two viruses are different.
PMID: 20130050 [PubMed - as supplied by publisher]
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8. J Virol. 2010 Feb 3. [Epub ahead of print]
Killing of avian and swine influenza by Natural Killer cells.
Achdout H, Segman T, Hirsh S, Glasner A, Bar-On Y, Gur C, Porgador A, Mendelson M, Mandelboim M, Mandelboim O. - The Lautenberg Center for general and Tumor Immunology, IMRIC, the Hebrew University Hadassah Medical School, Jerusalem, Israel; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel; Central Virology Laboratory, Ministry of Health, Public health Services, Chaim, Sheba medical Center, Tel Hashomer, Ramat-Gan Israel; Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and Cancer Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Today, a global attention is focused on two influenza virus strains, the current pandemic strain, swine-origin influenza virus (H1N1-2009) and the highly pathogenic avian influenza, H5N1. As for now, the infection caused by the H1N1-2009 is moderate with mortality rates of less than 1%. In contrast, infection with the H5N1 virus resulted in high mortality rates and around 60% of the infected patients succumb to the infection. Thus, one of the world greatest concerns is that the H5N1 virus will evolve to allow an efficient human infection and human-to-human transmission. Natural killer (NK) cells are one of the innate immune components playing an important role in fighting against influenza viruses. One of the major NK activating receptors involved in NK cell cytotoxicity is NKp46. We previously demonstrated that NKp46 recognizes the hemagglutinin proteins of B and A influenza virus strains. Whereas NKp46 could also interact with H1N1-2009 virus or with the avian influenza virus is still unknown. Here we analyzed the immunological properties of both the avian and the H1N1-2009 influenza viruses. We show that NKp46 recognizes the hemagglutinins of H1N1-2009 and H5 and that this recognition leads to virus killing both in vitro and in vivo. However, importantly, while the swine H1-NKp46 interactions lead to the direct killing of the infected cells, the H5-NKp46 interactions were unable to elicit direct killing, probably because the NKp46 binding sites for these two viruses are different.
PMID: 20130050 [PubMed - as supplied by publisher]
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