Giuseppe
Emeritus
Geographical spread of highly pathogenic Avian Influenza Virus (HPAIV) H5N1 during the 2006 outbreak in Austria. (J Virol., abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 24. [Epub ahead of print]
Geographical spread of highly pathogenic Avian Influenza Virus (HPAIV) H5N1 during the 2006 outbreak in Austria.
Fink M, Revilla Fern?ndez S, Schobesberger H, Koefer J. - Institute for Veterinary Disease Control, Moedling, Robert Koch Gasse 17, A-2340 Moedling.
In spring 2006, highly pathogenic avian influenza virus (HPAIV) of subtype H5N1 was detected in Austria in 119 dead wild birds. The hemagglutinin cleavage site showed the amino-acid sequence motif identical to the Qinghai lineage. For detailed analysis, the hemagglutinin (HA) and neuraminidase (NA) genes of 27 selected Austrian H5N1 viruses originating from different regions and wild bird species were analysed phylogenetically, which revealed two clearly separated Austrian subclusters, both belonging to European cluster EMA-1. Subcluster South (SCS) comprehends virus isolates from the south of Austria as well as from Slovenia, Turkey, Egypt and Nigeria. The second subcluster, Northwest (SCN), covered a larger group of viruses originating from different locations and wild bird species in the northern and very western parts of Austria as well as from Bavaria and Switzerland. Surprisingly, virus isolates originating from two mute swans and one wild duck found on the north side of the Alps did not cluster with SCN, but with SCS. Together with isolates from Bavarian, Czech Republic, Italy and Slovakia they form a genuine subgroup, named subgroup Bavaria (SGB). This subgroup forms a link to SCN indicating a spread of the virus from south to north. There has been a general assumption that the generic HPAI introduction route into Europe was from Russia to North Germany introducing cluster EMA-2 into Europe. Interestingly, our findings support the assumption of an alternative introduction of the HPAI H5N1 virus from Turkey to Central Europe where it spread as Cluster EMA-1 during the outbreak 2006.
PMID: 20335251 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 24. [Epub ahead of print]
Geographical spread of highly pathogenic Avian Influenza Virus (HPAIV) H5N1 during the 2006 outbreak in Austria.
Fink M, Revilla Fern?ndez S, Schobesberger H, Koefer J. - Institute for Veterinary Disease Control, Moedling, Robert Koch Gasse 17, A-2340 Moedling.
In spring 2006, highly pathogenic avian influenza virus (HPAIV) of subtype H5N1 was detected in Austria in 119 dead wild birds. The hemagglutinin cleavage site showed the amino-acid sequence motif identical to the Qinghai lineage. For detailed analysis, the hemagglutinin (HA) and neuraminidase (NA) genes of 27 selected Austrian H5N1 viruses originating from different regions and wild bird species were analysed phylogenetically, which revealed two clearly separated Austrian subclusters, both belonging to European cluster EMA-1. Subcluster South (SCS) comprehends virus isolates from the south of Austria as well as from Slovenia, Turkey, Egypt and Nigeria. The second subcluster, Northwest (SCN), covered a larger group of viruses originating from different locations and wild bird species in the northern and very western parts of Austria as well as from Bavaria and Switzerland. Surprisingly, virus isolates originating from two mute swans and one wild duck found on the north side of the Alps did not cluster with SCN, but with SCS. Together with isolates from Bavarian, Czech Republic, Italy and Slovakia they form a genuine subgroup, named subgroup Bavaria (SGB). This subgroup forms a link to SCN indicating a spread of the virus from south to north. There has been a general assumption that the generic HPAI introduction route into Europe was from Russia to North Germany introducing cluster EMA-2 into Europe. Interestingly, our findings support the assumption of an alternative introduction of the HPAI H5N1 virus from Turkey to Central Europe where it spread as Cluster EMA-1 during the outbreak 2006.
PMID: 20335251 [PubMed - as supplied by publisher]
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