Giuseppe
Emeritus
Evolutionary Dynamics of Multiple Sublineages of H5N1 Influenza Viruses in Nigeria, 2006-2008. (J Virol., abstract, edited)
J Virol. 2010 Jan 13. [Epub ahead of print]
Evolutionary Dynamics of Multiple Sublineages of H5N1 Influenza Viruses in Nigeria, 2006-2008.
Fusaro A, Nelson MI, Joannis T, Bertolotti L, Monne I, Salviato A, Olaleye O, Shittu I, Sulaiman L, Lombin LH, Capua I, Holmes EC, Cattoli G. - Istituto Zooprofilattico Sperimentale delle Venezie, Research & Development Department, OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Epidemiology, Training and Control of Emerging Avian Diseases, Viale dell'Universit? 10, Legnaro, Padova, Italy; Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America; National Veterinary Research Institute, P.M.B. 01 VOM, Plateau State, Nigeria; Dept. of Animal Productions, Epidemiology and Ecology, University of Torino, Faculty of Veterinary Medicine, Gugliasco (TO), Italy; Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, United States of America; Virology Department, University College Hospital, University of Ibadan, Ibadan, Nigeria.
Highly pathogenic A/H5N1 avian influenza viruses (HPAI H5N1) have seriously affected the Nigerian poultry industry since early 2006. Previous studies have identified multiple introductions of the virus into Nigeria and several reassortment events between co-circulating lineages. To determine the spatial, evolutionary, and population dynamics of the multiple H5N1 lineages co-circulating in Nigeria, we conducted a phylogenetic analysis of whole-genome sequences from 106 HPAI H5N1 viruses isolated between 2006-2008 and representing all 25 Nigerian states and the Federal Capital Territory (FCT) reporting outbreaks. We identified a major new sub-clade in Nigeria that is phylogenetically distinguishable from all previously identified sublineages, as well as two novel reassortment events. A detailed analysis of viral phylogeography identified two major source populations for the HPAI H5N1 virus in Nigeria, one in a major commercial poultry area (southwest region) and one in northern Nigeria, where contact between wild birds and backyard poultry is frequent. These findings suggested that migratory birds from Eastern Europe or Russia may serve an important role in the introduction of HPAI H5N1 viruses into Nigeria, although virus spread through the movement of poultry and poultry products cannot be excluded. Our study provides new insight into the genesis and evolution of H5N1 influenza viruses in Nigeria and has important implications for targeting surveillance efforts to rapidly identify the spread of the virus into and within Nigeria.
PMID: 20071565 [PubMed - as supplied by publisher]
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J Virol. 2010 Jan 13. [Epub ahead of print]
Evolutionary Dynamics of Multiple Sublineages of H5N1 Influenza Viruses in Nigeria, 2006-2008.
Fusaro A, Nelson MI, Joannis T, Bertolotti L, Monne I, Salviato A, Olaleye O, Shittu I, Sulaiman L, Lombin LH, Capua I, Holmes EC, Cattoli G. - Istituto Zooprofilattico Sperimentale delle Venezie, Research & Development Department, OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Epidemiology, Training and Control of Emerging Avian Diseases, Viale dell'Universit? 10, Legnaro, Padova, Italy; Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America; National Veterinary Research Institute, P.M.B. 01 VOM, Plateau State, Nigeria; Dept. of Animal Productions, Epidemiology and Ecology, University of Torino, Faculty of Veterinary Medicine, Gugliasco (TO), Italy; Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, United States of America; Virology Department, University College Hospital, University of Ibadan, Ibadan, Nigeria.
Highly pathogenic A/H5N1 avian influenza viruses (HPAI H5N1) have seriously affected the Nigerian poultry industry since early 2006. Previous studies have identified multiple introductions of the virus into Nigeria and several reassortment events between co-circulating lineages. To determine the spatial, evolutionary, and population dynamics of the multiple H5N1 lineages co-circulating in Nigeria, we conducted a phylogenetic analysis of whole-genome sequences from 106 HPAI H5N1 viruses isolated between 2006-2008 and representing all 25 Nigerian states and the Federal Capital Territory (FCT) reporting outbreaks. We identified a major new sub-clade in Nigeria that is phylogenetically distinguishable from all previously identified sublineages, as well as two novel reassortment events. A detailed analysis of viral phylogeography identified two major source populations for the HPAI H5N1 virus in Nigeria, one in a major commercial poultry area (southwest region) and one in northern Nigeria, where contact between wild birds and backyard poultry is frequent. These findings suggested that migratory birds from Eastern Europe or Russia may serve an important role in the introduction of HPAI H5N1 viruses into Nigeria, although virus spread through the movement of poultry and poultry products cannot be excluded. Our study provides new insight into the genesis and evolution of H5N1 influenza viruses in Nigeria and has important implications for targeting surveillance efforts to rapidly identify the spread of the virus into and within Nigeria.
PMID: 20071565 [PubMed - as supplied by publisher]
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